2-Phenyl-5-benzimidazolessigsaeure | 97194-38-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-Phenyl-5-benzimidazolessigsaeure
• 英文别名: (2-phenyl-1(3)H-benzoimidazol-5-yl)-acetic acid；2-(2-phenyl-3H-benzimidazol-5-yl)acetic acid
• CAS: 97194-38-2
• 化学式: C₁₅H₁₂N₂O₂
• 分子量: 252.272
• InChiKey: CJOGTBDZYPBCFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  66
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• BENZIMIDAZOL DERIVATIVES FOR TREATING FILOVIRUS INFECTION
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

  公开号：EP3296297A1

  公开（公告）日：2018-03-21

  The present invention relates to compounds comprising a benzimidazole scaffold, and the use of such compounds for the treatment of viral diseases. The invention also relates to pharmaceutical compositions comprising said compounds as an active ingredient. In particular the compounds of the invention comprising a benzimidazole scaffold are used for the treatment of filoviruses or retroviruses, and preferably for the treatment of Ebola virus or HIV virus.

  本发明涉及包含苯并咪唑支架的化合物，以及使用此类化合物治疗病毒性疾病。本发明还涉及包含上述化合物作为活性成分的药物组合物。 特别是包含苯并咪唑支架的本发明化合物可用于治疗丝状病毒或逆转录病毒，最好用于治疗埃博拉病毒或艾滋病毒。
• BENZAZOLES: BENZOXAZOLE, BENZTHIAZOLE AND BENZIMIDAZOLE DERIVATIVES
  申请人：Zeneca Limited

  公开号：EP1100798A1

  公开（公告）日：2001-05-23
• BENZAZOLE, BENZOXAZOLE, BENZTHIAZOLE AND BENZIMIDAZOLE DERIVATIVES
  申请人：Syngenta Limited

  公开号：EP1100798B1

  公开（公告）日：2002-09-18
• [EN] BENZAZOLES: BENZOXAZOLE, BENZTHIAZOLE AND BENZIMIDAZOLE DERIVATIVES<br/>[FR] DERIVES DE BENZOXAZOLE, BENZTHIAZOLE ET BENZIMIDAZOLE
  申请人：ZENECA LTD

  公开号：WO2000006566A1

  公开（公告）日：2000-02-10

  A compund of formula (I) wherein X is O or S; n is 0 or 1; Y is O, S or NR7; R1 is hydrogen, halogen, C¿1-6? aklyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 alkylthio, C1-6 haloalkylthio, C3-6 cycloalkyl, C1-6 alkoxy(C1-6)alkyl or SF5; R?2¿ is hydrogen, halogen, C¿1-6? alkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 alkylthio, C1-6 haloalkylthio, C1-6 alkylsulfinyl, C1-6 haloalkylsulfinyl, C1-6 alkylsulfonyl, C1-6 haloalkylsulfonyl, C1-6 haloalkyl, cyano, nitro, CHO, CH=NOR?5, C¿1-6 alkylcarbonyl, C1-6 alkoxycarbonyl or SF5; or together R?1 and R2¿ form a five or six membered saturated or unsturated carbocyclic ring, optionally substituted processes for preparing these compounds, compositions comprising them, methods of using them to combat fungal diseases and methods of using them to combat or control insect, acarine, mollusc and nematode pests.