p-nitrophenylhydrazine | 22719-27-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: p-nitrophenylhydrazine
• 英文别名: p-Nitro-phenyl-diazen；4-Nitro-phenyldiazen；p-Nitrophenyldiazen；Diazobenzene, 4-nitro-；(4-nitrophenyl)diazene
• CAS: 22719-27-3；112240-55-8；112240-56-9
• 化学式: C₆H₅N₃O₂
• 分子量: 151.125
• InChiKey: JUUXYSDWEGIGHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  82
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  p-nitrophenylhydrazine 、 1,10-菲咯啉-4,7-二甲醛 以 乙醇 为溶剂， 反应 6.0h， 生成
  参考文献：
  名称：

  Color responses of novel receptors for AcO− and a test paper for AcO− in pure aqueous solution

  摘要：

  An efficient AcO- sensor L which contains 1,10-phenanthroline-based and nitrophenylhydrazine-based groups, and its water-soluble Ru(II) complex were synthesized, characterized and studied in this Letter. Via UV-vis experiments and H-1 NMR titration in DMSO solution, it was found that there were potential hydrogen bonds between the N=CH and AcO- after the deprotanation of two-NH during the reaction of L or its Ru complex with anions. Furthermore, an easy-to-prepare test paper was developed to detect AcO- at 10 mg/L in pure aqueous solution. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.10.034

文献信息

• ANTI-INFECTIVE AGENTS AGAINST INTRACELLULAR PATHOGENS
  申请人：Chen Ching-Shih

  公开号：US20090111799A1

  公开（公告）日：2009-04-30

  A new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of Formula I: wherein X wherein X is —CF 3 , Ar is selected from and R is selected from where R′ is L-Lys, D-Lys, β-Ala, L-Lue, L-Ile, Phe, SO 2 CH 2 CH 2 NH 2 , SO 2 NH 2 , Asn, Glu or Gyl, and R″ is methyl, ethyl, allyl, CH 2 CH 2 OH, CH 2 CN, CH 2 CH 2 CN, CH 2 CONH 2 ,

  一种新的磷脂酰肌醇依赖激酶-1（PDK-1）抑制剂的化学式I：其中X为—CF3，Ar从中选择，R从中选择，其中R′为L-赖氨酸，D-赖氨酸，β-丙氨酸，L-亮氨酸，L-异亮氨酸，苯丙氨酸，SO2CH2CH2NH2，SO2NH2，天冬氨酸，谷氨酸或甘氨酸，R″为甲基，乙基，烯丙基，CH2CH2OH，CH2CN，CH2CH2CN，CH2CONH2。
• [EN] NEW PROCESS FOR PREPARING ARYLBORANES BY ARYLATION OF ORGANOBORON COMPOUNDS<br/>[FR] NOUVEAU PROCÉDÉ POUR LA PRÉPARATION D'ARYLBORANES PAR ARYLATION DE COMPOSÉS ORGANOBORÉS
  申请人：UNIV BORDEAUX 1

  公开号：WO2014009169A1

  公开（公告）日：2014-01-16

  The present invention relates to a new process for the preparation of an arylborane compound, by arylation of a B-H bond, which comprises a step (1) of contacting an arenediazonium salt or a heteroarenediazonium salt with an organoboron compound containing at least one B-H bond, in a reaction medium containing a solvent, in the absence of base, in the absence or in the presence of an activating agent, for the preparation of an arylborane compound, and a possible step (2) of recovery and purification of said arylborane compound obtained at the step (1), said arylborane being in particular an aminoarylborane, and a possible step (3) of refunctionalisation of said arylborane obtained at step (1) or (2) for the preparation of aryl boronic derivatives or arylborates.

  本发明涉及一种制备芳基硼烷化合物的新工艺，通过芳基硼-氢键的芳基化，包括以下步骤：(1)将芳基重氮盐或杂环芳基重氮盐与至少含有一个硼-氢键的有机硼化合物在反应介质中接触，所述反应介质包含溶剂，在无碱的情况下，在缺乏或存在活化剂的情况下，用于制备芳基硼烷化合物，并可能进行(2)步骤以回收和纯化在步骤(1)中得到的所述芳基硼烷化合物，所述芳基硼烷化合物特别是氨基芳基硼烷，以及可能进行(3)步骤对在步骤(1)或(2)中得到的所述芳基硼烷进行重官能化，用于制备芳基硼酸衍生物或芳基硼酸酯。
• Novel dinuclear metal complex and pyrophosphate assay using the same
  申请人：Hong Jong-In

  公开号：US20050119497A1

  公开（公告）日：2005-06-02

  A novel coordination complex formed by dinuclear metal complexation is provided. The complex is a dinuclear metal complex of a compound, wherein the compound comprises a conjugation ring system substituted with: a) an electron donating group selected from —OH, —SH and —NH 2 ; b) an indicating group selected from a chromogenic group, a fluorescent group and an electrochemical group; and c) two binding auxiliary groups, in combination with the electron donating group each of which being coordinated with the metal to provide an anion bonding site, wherein as the complex binds to a anion, the coordination of the electron donating group with the metal is weakened and electron donation of the electron donating group to the conjugation ring system is reinforced such that the reinforced electron donation by the electron donating group is transferred through the conjugation ring system to the indicating group to produce an indicating signal concomitant with the change of its electronic density. The coordination complex shows high sensitivity and high selectivity for pyrophosphate over other anions in an aqueous solvent over a wide pH range. Therefore, the complex is useful for pyrophosphate assay as a pyrophosphate sensor.

  提供了一种由双核金属络合形成的新型配位化合物。该配合物是一种化合物的双核金属络合物，其中该化合物包括一个带有以下取代基的共轭环系统：a) 从—OH、—SH和—NH2中选择的电子给体基团；b) 从显色基团、荧光基团和电化学基团中选择的指示基团；以及c) 两个结合辅助基团，与电子给体基团结合在一起，每个结合辅助基团与金属配位以提供一个阴离子结合位点，当该配合物与阴离子结合时，电子给体基团与金属的配位被削弱，电子给体基团向共轭环系统的电子给体作用被加强，从而通过共轭环系统向指示基团传递加强的电子给体作用，产生与其电子密度变化相伴随的指示信号。该配位化合物在广泛的pH范围内对焦磷酸盐的灵敏度和选择性很高，优于其他阴离子在水溶剂中。因此，该复合物作为焦磷酸盐传感器对焦磷酸盐的检测是有用的。
• [EN] OXAZINE DYES WITH IMPROVED AQUEOUS SOLUBILITY<br/>[FR] COLORANTS À BASE D'OXAZINE PRÉSENTANT UNE SOLUBILITÉ AQUEUSE AMÉLIORÉE
  申请人：SIGMA ALDRICH CO

  公开号：WO2009152024A1

  公开（公告）日：2009-12-17

  The present invention provides oxazine dyes, processes for preparing the oxazine dyes, intermediates that may be utilized in the processes for preparing the oxazine dyes, and methods for using the oxazine dyes.

  本发明提供了噁嗪染料、制备噁嗪染料的方法、可用于制备噁嗪染料的中间体，以及使用噁嗪染料的方法。
• Colorimetric detection of cyanide with a chromogenic oxazine
  申请人：Raymo Francisco M.

  公开号：US20090258429A1

  公开（公告）日：2009-10-15

  A chromogenic oxazine compound for the colorimetric detection of cyanide was designed. Indeed, the [1,3]oxazine ring of our compound opens to form a phenolate chromophore in response to cyanide. The heterocyclic com-pound may be comprised of fused benzooxazine and indoline rings: wherein R 1 is an alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, isobutyl), a substituted alkyl, a cycloalkyl (e.g., cyclopentyl, cyclohexyl), a substituted cycloalkyl, an aryl (e.g., phenyl), or a substituted aryl and R 2 is a chromophore (e.g., nitroso, nitro, azo dyes). This quantitative chromogenic transformation permits the detection of micromolar concentrations of cyanide in water. Furthermore, our chromogenic oxazine is insensitive to the presence of large concentrations of fluoride, chloride, bromide or iodide anions, which are generally the principal interferents in the colorimetric detection of cyanide.

  设计了一种用于比色检测氰化物的发色氧杂芴化合物。实际上，我们化合物的[1,3]氧杂芴环会在氰化物的作用下打开，形成酚酸色团。这种杂环化合物可能由融合的苯氧杂芴和吲哚环组成：其中R1是烷基（例如，甲基，乙基，丙基，异丙基，丁基，异丁基），取代烷基，环烷基（例如，环戊基，环己基），取代环烷基，芳基（例如，苯基），或取代芳基，而R2是色团（例如，亚硝基，硝基，偶氮染料）。这种定量的发色转化允许在水中检测微摩尔浓度的氰化物。此外，我们的发色氧杂芴对氟化物，氯化物，溴化物或碘化物阴离子的大浓度存在不敏感，这些通常是影响氰化物比色检测的主要干扰物质。