N-{[(2,4-dimethoxyphenyl)dimethylsilanyl]methyl}-N-isopropylsuccinamic acid | 1051316-53-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-{[(2,4-dimethoxyphenyl)dimethylsilanyl]methyl}-N-isopropylsuccinamic acid
• CAS: 1051316-53-0
• 化学式: C₁₈H₂₉NO₅Si
• 分子量: 367.517
• InChiKey: VFZMWCBWJRHYMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.26
• 重原子数：
  25.0
• 可旋转键数：
  9.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  76.07
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  N-羟基丁二酰亚胺 、 N-{[(2,4-dimethoxyphenyl)dimethylsilanyl]methyl}-N-isopropylsuccinamic acid 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以72%的产率得到N-{[(2,4-dimethoxyphenyl)dimethylsilanyl]methyl}-N-isopropylsuccinamic acid 2,5-dioxopyrrolidin-1-yl ester
  参考文献：
  名称：

  Microelectrode Arrays and Ceric Ammonium Nitrate: A Simple Strategy for Developing New Site-Selective Synthetic Methods

  摘要：

  Conditions for a site-selective ceric ammonium nitrate oxidation have been developed. The reactions proceed nicely on both 1K- and 12K-microelectrode arrays. The procedure for developing the reactions was very simple and demonstrated that the same reagents used for a solution-phase reaction can be used for a related site-selective reaction on a microelectrode array.

  DOI：

  10.1021/ja804661h
• 作为产物：
  描述：

  N-{[(2,4-dimethoxyphenyl)dimethylsilanyl]methyl}-N-isopropylsuccinamic acid methyl ester 在 sodium hydroxide 作用下， 以 乙醚 、 水 为溶剂， 反应 2.0h， 以83%的产率得到N-{[(2,4-dimethoxyphenyl)dimethylsilanyl]methyl}-N-isopropylsuccinamic acid
  参考文献：
  名称：

  Microelectrode Arrays and Ceric Ammonium Nitrate: A Simple Strategy for Developing New Site-Selective Synthetic Methods

  摘要：

  Conditions for a site-selective ceric ammonium nitrate oxidation have been developed. The reactions proceed nicely on both 1K- and 12K-microelectrode arrays. The procedure for developing the reactions was very simple and demonstrated that the same reagents used for a solution-phase reaction can be used for a related site-selective reaction on a microelectrode array.

  DOI：

  10.1021/ja804661h