[carboxy-14C]Picolinic acid | 40167-46-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: [carboxy-14C]Picolinic acid
• 英文别名: Picolinsaeure-(carboxyl-14C)；pyridine-2-carboxylic acid
• CAS: 40167-46-2
• 化学式: C₆H₅NO₂
• 分子量: 125.1
• InChiKey: SIOXPEMLGUPBBT-ZQBYOMGUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.78
• 重原子数：
  9.0
• 可旋转键数：
  1.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.19
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  1-苄基哌嗪 、 [carboxy-14C]Picolinic acid 生成 (4-benzylpiperazin-1-yl)-pyridin-2-yl(114C)methanone
  参考文献：
  名称：

  ZOLYOMI G.; BUDAI Z., J. LABELLED COMPOUNDS AND RADIOPHARM., 1981, 18, NO 3, 427-432

  摘要：

  DOI：
• 作为产物：
  描述：

  2-溴吡啶 、 二氧化碳-14C 在 正丁基锂 作用下， 生成 [carboxy-14C]Picolinic acid
  参考文献：
  名称：

  Phloem translocation of pyridinecarboxylic acids and related imidazolinone herbicides inRicinus communis

  摘要：

  AbstractThe movement of [14C]pyridinecarboxylic acids was investigated in the castor bean plant Ricinus communis L. after application by petiole injection. The three isomeric unsubstituted acids appeared in similar concentrations in phloem sap taken from the upper main stem over a period of 6 h after application, but nicotinic acid occurred at higher concentrations than its isomers in phloem sap from the lower stem indicating better retention in the phloem sieve tubes. After 24 h, nicotinic acid had accumulated to a greater extent in the phloem sinks than had picolinic or isonicotinic acids. Phloem transport of substituted analogues, including dihalopyridinecarboxylic acids and imidazolinone herbicides, was measured in short‐term tests, and attempts made to relate such transport to the lipophilicity and pK,a of the compounds. Analogues of the imidazolinone, imazapyr, were less well transported than imazapyr itself, and were also much less well taken up by barley roots from nutrient solution compared to the herbicidal imidazolinone, and this could explain their low herbicidal efficacy despite a high intrinsic activity against the target enzyme acctolactate synthase.

  DOI：

  10.1002/ps.2780450110