magnesium salt of propargyl benzyl ether | 118972-91-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: magnesium salt of propargyl benzyl ether
• CAS: 118972-91-1
• 化学式: C₁₀H₉BrMgO
• 分子量: 249.39
• InChiKey: YFWRBBDIBCFTSL-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  2.18
• 重原子数：
  13.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  9.23
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  3-邻苯二甲酰亚胺丙醛 、 magnesium salt of propargyl benzyl ether 以 四氢呋喃 为溶剂， 以56%的产率得到2-(3-hydroxy-6-phenylmethoxyhex-4-ynyl)isoindole-1,3-dione
  参考文献：
  名称：

  立体选择性合成（±）-苏式-γ-羟基-β-赖氨酸内酯

  摘要：

  报道了外消旋苏-γ-羟基-β-赖氨酸的立体选择性合成。巯基氨基醇官能团是通过汞离子引发的酰基氨基甲基醚4a的环官能化引入的。

  DOI：

  10.1016/s0040-4039(00)82116-4

文献信息

• Divergent Method to <i>trans</i>-5-Hydroxy-6-alkynyl/alkenyl-2-piperidinones: Syntheses of (−)-Epiquinamide and (+)-Swainsonine
  作者：Chang-Mei Si、Zhuo-Ya Mao、Han-Qing Dong、Zhen-Ting Du、Bang-Guo Wei、Guo-Qiang Lin

  DOI：10.1021/acs.joc.5b00803

  日期：2015.6.5

  An efficient diastereoselective approach to access trans-5-hydroxy-6-alkynyl/alkenyl-2-piperidinones has been developed through nucleophilic addition of α-chiral aldimines using alkynyl/alkenyl Grignard reagents. The diastereoselectivity of alkenyl in C-6 position of 2-piperidinone was controlled by α-alkoxy substitution, while the alkynyl was controlled by the coordination of the α-alkoxy substitution

  通过使用炔基/烯基格利雅试剂试剂亲核加成α-手性醛亚胺，已经开发了一种有效的非对映选择性方法，可用于反式-5-羟基-6-炔基/烯基-2-哌啶酮。α-烷氧基取代控制2-哌啶酮C-6位置链烯基的非对映选择性，而α-烷氧基取代和亚磺酰胺的立体化学则控制炔基。（-）-表喹酰胺和（+）-swainsonine的不对称合成证明了这种简单的级联过程的实用性。
• Synthesis of α-Substituted Allylic Amines via a Modified Bruylants Reaction
  作者：Claude Agami、François Couty、Gwilherm Evano

  DOI：10.1021/ol0059908

  日期：2000.7.1

  iminium ion promoter from alpha-amino nitriles, is an efficient additive in the Bruylants reaction involving vinylic Grignards. Improved yields of allylic amines were obtained when the starting alpha-amino nitrile was treated with this silver salt prior to its reaction with the vinylic Grignard. This improvement was not observed in the case of acetylenic Grignards. The reactivity of other vinyl organometallics

  四氟硼酸银，用作α-氨基腈的亚胺离子促进剂，在涉及乙烯基格氏试剂的Bruylants反应中是一种有效的添加剂。在这种银盐与乙烯基格氏试剂反应之前，用这种银盐处理起始的α-氨基腈，可以提高烯丙基胺的收率。在炔属格氏试剂中未观察到这种改善。简要检查了其他乙烯基有机金属（M = Zn，Li，Al，Cu，Si）的反应性。
• Remote control by protecting groups in the diastereoselective addition of acetylides to 2-(4-quinolyl)propanol
  作者：Giuseppe Guanti、Sara Perrozzi、Renata Riva

  DOI：10.1016/s0957-4166(98)00418-2

  日期：1998.11

  Differently O-protected 2-(4-quinolyl)propanols undergo, in the presence of chloroformate esters, a regio- and stereoselective addition of acetylides on the carbon alpha to nitrogen with moderate to good diastereoselectivity. The bulkiness of the OH protecting group, which has a 1,7 relationship with the newly created stereocentre, appears to be mainly responsible for this remote stereocontrol. (C) 1998 Elsevier Science Ltd. All rights reserved.