6-fluoro-[1,1'-biphenyl]-3-amine | 103977-88-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-fluoro-[1,1'-biphenyl]-3-amine
• 英文别名: 3-amino-6-fluorobiphenyl；4-fluoro-3-phenylaniline；5-amino-2-fluorobiphenyl
• CAS: 103977-88-4
• 化学式: C₁₂H₁₀FN
• 分子量: 187.217
• InChiKey: KGHJSTHVTOSNLM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-fluoro-[1,1'-biphenyl]-3-amine 在 tin(II) chloride dihdyrate 作用下， 以 甲醇 、 乙酸乙酯 为溶剂， 反应 3.58h， 生成 N-((1-(2-amino-4-chlorobenzyl)-1H-imidazol-5-yl)methyl)-6-fluoro-[1,1'-biphenyl]-3-amine
  参考文献：
  名称：

  Dialkylimidazole inhibitors of Trypanosoma cruzi sterol 14α-demethylase as anti-Chagas disease agents

  摘要：

  New dialkylimidazole based sterol 14 alpha-demethylase inhibitors were prepared and tested as potential anti-Trypanosoma cruzi agents. Previous studies had identified compound 2 as the most potent and selective inhibitor against parasite cultures. In addition, animal studies had demonstrated that compound 2 is highly efficacious in the acute model of the disease. However, compound 2 has a high molecular weight and high hydrophobicity, issues addressed here. Systematic modifications were carried out at four positions on the scaffold and several inhibitors were identified which are highly potent (EC50 <1 nM)against T. cruzi in culture. The halogenated derivatives 36j, 36k, and 36p, display excellent activity against T. cruzi amastigotes, with reduced molecular weight and lipophilicity, and exhibit suitable physicochemical properties for an oral drug candidate. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.08.015
• 作为产物：
  描述：

  2-氟-5-硝基联苯 在 tin(II) chloride dihdyrate 作用下， 以 乙酸乙酯 为溶剂， 反应 2.5h， 生成 6-fluoro-[1,1'-biphenyl]-3-amine
  参考文献：
  名称：

  Dialkylimidazole inhibitors of Trypanosoma cruzi sterol 14α-demethylase as anti-Chagas disease agents

  摘要：

  New dialkylimidazole based sterol 14 alpha-demethylase inhibitors were prepared and tested as potential anti-Trypanosoma cruzi agents. Previous studies had identified compound 2 as the most potent and selective inhibitor against parasite cultures. In addition, animal studies had demonstrated that compound 2 is highly efficacious in the acute model of the disease. However, compound 2 has a high molecular weight and high hydrophobicity, issues addressed here. Systematic modifications were carried out at four positions on the scaffold and several inhibitors were identified which are highly potent (EC50 <1 nM)against T. cruzi in culture. The halogenated derivatives 36j, 36k, and 36p, display excellent activity against T. cruzi amastigotes, with reduced molecular weight and lipophilicity, and exhibit suitable physicochemical properties for an oral drug candidate. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.08.015

文献信息

• Antibiotic derivatives of
  申请人：Pfizer Inc.

  公开号：US04623650A1

  公开（公告）日：1986-11-18

  1-Substituted-6-fluoro-7-aryl-(8-fluoro)-1,4-dihydroquinol-4-one 3-carboxylic acids having antibacterial activity are prepared by reacting the corresponding alkyl 1-substituted-6-fluoro-7-bromo-(8-fluoro)-1,4-dihydroquinol-4-one-3-carbox ylate with an arylmetallic compound and hydrolyzing the ester formed.

  具有抗菌活性的1-取代-6-氟-7-芳基-(8-氟)-1,4-二氢喹啉-4-酮3-羧酸是通过将相应的烷基1-取代-6-氟-7-溴-(8-氟)-1,4-二氢喹啉-4-酮-3-羧酸酯与芳基金属化合物反应，并水解形成的酯来制备的。
• NOVEL HETEROCYCLIC COMPOUNDS AS PESTICIDES
  申请人：Bayer CropScience Aktiengesellschaft

  公开号：US20200062729A1

  公开（公告）日：2020-02-27

  The invention relates to novel compounds of the formula (I) in which Z, Y, A 1 , A 2 , A 3 , A 4 , X, R 7 , R 8 and R 9 have the meanings mentioned above, and processes and intermediates for the preparation thereof, and their use for controlling animal pests, in particular insects.

  该发明涉及公式（I）中的新化合物，其中Z、Y、A1、A2、A3、A4、X、R7、R8和R9具有上述提及的含义，以及其制备的过程和中间体，以及它们用于控制动物害虫，特别是昆虫。
• METHOD FOR PRODUCING BIARYL COMPOUND
  申请人：Sato Koichi

  公开号：US20100087680A1

  公开（公告）日：2010-04-08

  A method for producing a biaryl compound, comprising reacting an aromatic organic compound with at least one compound selected from the group consisting of aromatic organoboron compounds and boroxine compounds, in the presence of a zero-valent nickel catalyst, phosphine ligand and base.

  一种制备双芳基化合物的方法，包括在零价镍催化剂、膦配体和碱的存在下，将芳香有机化合物与选自芳香基有机硼化合物和硼氧化物化合物组的至少一种化合物反应。
• PROCESS FOR PRODUCING BIARYL COMPOUND
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP1914221A1

  公开（公告）日：2008-04-23

  A method for producing a biaryl compound, comprising reacting an aromatic organic compound with at least one compound selected from the group consisting of aromatic organoboron compounds and boroxine compounds, in the presence of a zero-valent nickel catalyst, phosphine ligand and base.

  一种生产双芳基化合物的方法，包括在零价镍催化剂、膦配体和碱存在下，使芳香族有机化合物与至少一种选自由芳香族有机硼化合物和硼氧化合物组成的组中的化合物反应。
• EP551518
  申请人：——

  公开号：——

  公开（公告）日：——