4-methyl-3a,4,5,7-tetrahydro-3H-pyrano[3,4-c][1,2]oxazole | 1220328-26-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: 4-methyl-3a,4,5,7-tetrahydro-3H-pyrano[3,4-c][1,2]oxazole
• CAS: 1220328-26-6
• 化学式: C₇H₁₁NO₂
• 分子量: 141.17
• InChiKey: QYNNXYPWEYDXBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  30.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• NOVEL FUSED AMINODIHYDROTHIAZINE DERIVATIVE
  申请人：Motoki Takafumi

  公开号：US20100093999A1

  公开（公告）日：2010-04-15

  A compound represented by the general formula: wherein Ring A is a C 6-14 aryl group or the like, L is —NR L CO— or the like (wherein R L is a hydrogen atom or the like), Ring B is a C 6-14 aryl group or the like, X is a C 1-3 alkylene group or the like, Y is a C 1-3 alkylene group or the like, Z is an oxygen atom or the like, R 1 and R 2 are each independently a hydrogen atom or the like, and R 3 , R 4 , R 5 and R 6 are independently a hydrogen atom, a halogen atom or the like, or a pharmaceutically acceptable salt thereof, or a solvate thereof, has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer-type dementia.

  一个由通式表示的化合物：其中环A是C6-14芳基或类似物，L是—NRLCO—或类似物（其中RL是氢原子或类似物），环B是C6-14芳基或类似物，X是C1-3烷基烯基或类似物，Y是C1-3烷基烯基或类似物，Z是氧原子或类似物，R1和R2分别是独立的氢原子或类似物，R3、R4、R5和R6独立地是氢原子、卤原子或类似物，或其药用可接受盐，或其溶剂化物，具有Aβ产生抑制作用或BACE1抑制作用，并且可用作治疗Aβ引起的以阿尔茨海默型痴呆为特征的神经退行性疾病的治疗剂。
• US8198269B2
  申请人：——

  公开号：US8198269B2

  公开（公告）日：2012-06-12