4-(3,4-methylenedioxyphenyl)-3-methylenepyrrolidin-2-one | 1042401-56-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 4-(3,4-methylenedioxyphenyl)-3-methylenepyrrolidin-2-one
• 英文别名: 4-(1,3-Benzodioxol-5-yl)-3-methylidenepyrrolidin-2-one
• CAS: 1042401-56-8
• 化学式: C₁₂H₁₁NO₃
• 分子量: 217.224
• InChiKey: FNMCMBQJQOCMAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  tert-butyl 4-(3,4-methylenedioxyphenyl)-3-methylene-2-oxopyrrolidine-1-carboxylate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以82%的产率得到4-(3,4-methylenedioxyphenyl)-3-methylenepyrrolidin-2-one
  参考文献：
  名称：

  A convenient synthesis and cytotoxic evaluation of N-unsubstituted α-methylene-γ-lactams

  摘要：

  Chemoselective reduction of 3-aryl-2-diethoxyphosphoryl-4-nitroalkanoates provided the corresponding alpha-diethoxyphosphoryl-gamma-lactams in completely diastereoselective manner. The products were shown to be useful substrates for the synthesis of mono-beta-substituted and beta,gamma-disubstituted alpha-methylene-gamma-lactams. Cytotoxicity of these compounds was evaluated. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.04.090

文献信息

• A convenient synthesis and cytotoxic evaluation of N-unsubstituted α-methylene-γ-lactams
  作者：Henryk Krawczyk、Łukasz Albrecht、Jakub Wojciechowski、Wojciech M. Wolf、Urszula Krajewska、Marek Różalski

  DOI：10.1016/j.tet.2008.04.090

  日期：2008.6

  Chemoselective reduction of 3-aryl-2-diethoxyphosphoryl-4-nitroalkanoates provided the corresponding alpha-diethoxyphosphoryl-gamma-lactams in completely diastereoselective manner. The products were shown to be useful substrates for the synthesis of mono-beta-substituted and beta,gamma-disubstituted alpha-methylene-gamma-lactams. Cytotoxicity of these compounds was evaluated. (C) 2008 Elsevier Ltd. All rights reserved.