[(4R)-4-[benzyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]pent-1-en-3-yl] ethyl carbonate | 201055-37-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(4R)-4-[benzyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]pent-1-en-3-yl] ethyl carbonate
• CAS: 201055-37-0
• 化学式: C₂₀H₂₉NO₅
• 分子量: 363.454
• InChiKey: VKCRTCWCQLZQGK-LDCVWXEPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  26
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  65.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  丙醛 、 [(4R)-4-[benzyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]pent-1-en-3-yl] ethyl carbonate 在 titanium(IV) isopropylate 、 异丙基氯化镁 作用下， 生成 tert-butyl N-benzyl-N-[(2R,3R,4R)-3-ethenyl-4-hydroxyhexan-2-yl]carbamate
  参考文献：
  名称：

  Synthesis of chiral allyltitaniums having an amino group at the C-4 position and their diastereoselective addition reaction with aldehydes

  摘要：

  Chiral allyltitaniums having an amino substituent at the C-4 position are prepared from optically active allylic alcohol derivatives 1 and Ti(O-i-Pr)(4)/2i-PrMgCl reagent, which, in turn, react with aldehydes regio-and stereoselectively to afford 3-amino-2-vinylalkanols in excellent yields. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)10367-7
• 作为产物：
  描述：

  (2R,3R)-3-(benzylamino)butane-1,2-diol 在 碳酸氢钠 作用下， 生成 [(4R)-4-[benzyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]pent-1-en-3-yl] ethyl carbonate
  参考文献：
  名称：

  Synthesis of chiral allyltitaniums having an amino group at the C-4 position and their diastereoselective addition reaction with aldehydes

  摘要：

  Chiral allyltitaniums having an amino substituent at the C-4 position are prepared from optically active allylic alcohol derivatives 1 and Ti(O-i-Pr)(4)/2i-PrMgCl reagent, which, in turn, react with aldehydes regio-and stereoselectively to afford 3-amino-2-vinylalkanols in excellent yields. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)10367-7

文献信息

• Synthesis of chiral allyltitaniums having an amino group at the C-4 position and their diastereoselective addition reaction with aldehydes
  作者：Xin Teng、Aleksandr Kasatkin、Yasufumi Kawanaka、Sentaro Okamoto、Fumie Sato

  DOI：10.1016/s0040-4039(97)10367-7

  日期：1997.12

  Chiral allyltitaniums having an amino substituent at the C-4 position are prepared from optically active allylic alcohol derivatives 1 and Ti(O-i-Pr)(4)/2i-PrMgCl reagent, which, in turn, react with aldehydes regio-and stereoselectively to afford 3-amino-2-vinylalkanols in excellent yields. (C) 1997 Elsevier Science Ltd.