N-(2-ethoxycarbonyl-phenyl)-glycine | 115210-51-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-ethoxycarbonyl-phenyl)-glycine
• 英文别名: N-(2-Aethoxycarbonyl-phenyl)-glycin；Phenylglycin-o-carbonsaeureaethylester；2-(2-Ethoxycarbonylanilino)acetic acid
• CAS: 115210-51-0
• 化学式: C₁₁H₁₃NO₄
• 分子量: 223.229
• InChiKey: RFLXIKBATYPHAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-(2-ethoxycarbonyl-phenyl)-glycine 在 lithium hydroxide 、 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 三乙胺 作用下， 生成
  参考文献：
  名称：

  Discovery of 1-(4-phenoxypiperidin-1-yl)-2-arylaminoethanone stearoyl-CoA desaturase 1 inhibitors

  摘要：

  A series of novel stearoyl-CoA desaturase 1 (SCD1) inhibitors were identified by scaffold design based on known SCD1 inhibitors. Large structural changes were made leading to multiple analogs with comparable or improved potency. This approach is valuable for generation of proprietary compounds without conducting a costly high-throughput screening. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.03.099
• 作为产物：
  描述：

  ethyl 2-[(2-ethoxy-2-oxo-ethyl)amino]benzoate 生成 N-(2-ethoxycarbonyl-phenyl)-glycine
  参考文献：
  名称：

  Vorlaender; v. Schilling, Chemische Berichte, 1900, vol. 33, p. 554

  摘要：

  DOI：

文献信息

• [EN] PROCESS OF PREPARATION OF OPTICALLY ACTIVE ALPHA AMINOACETALS<br/>[FR] PRÉPARATION D'ALPHA AMINOCÉTALS OPTIQUEMENT ACTIFS
  申请人：CLARIANT SPECIALTY FINE CHEM

  公开号：WO2009106386A1

  公开（公告）日：2009-09-03

  The invention relates to a process for preparing optically active α-aminoacetals by resolution of a racemic mixture or of a mixture of enantiomers via the formation of diastereoisomeric salts, and also novel intermediates in the form of diastereoisomeric salts.

  该发明涉及一种制备光学活性α-氨基缩醛的方法，通过分离外消旋混合物或对映异构体混合物，通过形成二对映异构盐，并且还涉及以二对映异构盐形式存在的新型中间体。
• Composition containing a penem or carbapenem antibiotic
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0178911A2

  公开（公告）日：1986-04-23

  57 Administration of an N-acylated amino acid (ornithine, lysine, phenylglycine or phenylalanine) in association with a penem or carbapenem antibiotic relieves or eliminates the renal problems associated with administration of the antibiotic alone. The amino acid and antibiotic may be formulated together as a composition or administered separately, either simultaneously or sequentially. A pharmaceutical composition may be prepared simply by mixing the two components.

  57 将 N-酰化氨基酸（鸟氨酸、赖氨酸、苯甘氨酸或苯丙氨酸）与培南类或碳青霉烯类抗生素联合给药，可缓解或消除与单独给药抗生素相关的肾脏问题。 氨基酸和抗生素可一起配制成组合物，也可同时或依次单独给药。 只需将两种成分混合即可制备成药物组合物。
• DE136779
  申请人：——

  公开号：——

  公开（公告）日：——
• DE122687
  申请人：——

  公开号：——

  公开（公告）日：——
• PROCESS OF PREPARATION OF OPTICALLY ACTIVE ALPHA AMINOACETALS
  申请人：Clariant Specialty Fine Chemicals (France)

  公开号：EP2245000B1

  公开（公告）日：2013-01-02