1-[2-[bis(chloromethyl)phosphoryloxy]phenyl]-N,N-dimethylmethanamine | 129379-65-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[2-[bis(chloromethyl)phosphoryloxy]phenyl]-N,N-dimethylmethanamine
• CAS: 129379-65-3
• 化学式: C₁₁H₁₆Cl₂NO₂P
• 分子量: 296.133
• InChiKey: RIRMACFZUZJJEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  17.0
• 可旋转键数：
  6.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  29.54
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  1-[2-[bis(chloromethyl)phosphoryloxy]phenyl]-N,N-dimethylmethanamine 、 水 生成 di(chloromethyl)phosphinic acid
  参考文献：
  名称：

  RYZHKINA, I. S.;KUDRYAVTSEVA, L. A.;BELSKIJ, V. E.;ISMAEV, I. EH.;MOROZOV+, ZH. OBSHCH. XIMII, 60,(1990) N, S. 820-827

  摘要：

  DOI：
• 作为产物：
  描述：

  2-二甲胺基甲基苯酚 、 4-nitrophenyl bis(chloromethyl)phosphinate 在 sodium dodecyl-sulfate 作用下， 以 水 为溶剂， 生成 1-[2-[bis(chloromethyl)phosphoryloxy]phenyl]-N,N-dimethylmethanamine
  参考文献：
  名称：

  Effect of sodium dodecyl sulfate on the reactivity of 2-dimethylaminomethylphenol with 4-nitrophenylbis(chloromethyl)phosphinate

  摘要：

  The reactivity of 2-dimethylaminomethylphenol (1) toward 4-nitrophenylbis (chloromethyl)phosphinate (2) was studied in micellar solutions and in the lyotropic liquid-crystalline mesophase of the sodium dodecyl sulfate (SDS)-water system. The reaction between 1 and 2 is inhibited in the presence of SDS, which is explained by the shift of the acid-base equilibrium of 1 toward the formation of a nonreactive protonated form.

  DOI：

  10.1007/bf00707216

文献信息

• The inverted micellar catalysis of the reaction of 2-aminomethylphenols with 4-nitrophenyl bis(chloromethyl)phosphinate
  作者：E. P. Zhil'tsova、L. A. Kudryavtseva、R. A. Shagidullina

  DOI：10.1007/bf02494546

  日期：1999.2

  The parameters of the reaction ofpara-substituted 2-aminomethylphenols with 4-nitrophenyl bis(chloromethyl)phosphinate in toluene catalyzed by reversed micelles of polyethylene glycol-600 monolaurate depend on the nucleophile structure. The efficiency of the catalytic action increases in the series of substitutes C9H19i

  聚乙二醇-600单月桂酸酯反胶束催化对位取代的2-氨基甲基苯酚与4-硝基苯基双(氯甲基)次膦酸酯在甲苯中的反应参数取决于亲核试剂的结构。C9H19i系列替代品催化作用效率提高
• Ryzhkina, I. S.; Kudryavtseva, L. A.; Bel'skii, V. E., Journal of general chemistry of the USSR, 1990, vol. 60, # 4.1, p. 718 - 725
  作者：Ryzhkina, I. S.、Kudryavtseva, L. A.、Bel'skii, V. E.、Ismaev, I. E.、Morozov, V. I.、et al.

  DOI：——

  日期：——
• ——
  作者：E. P. Zhil'tsova、A. P. Timosheva、L. A. Kudryavtseva、V. E. Kataev、Yu. I. Sal'nikov、I. S. Ryzhkina、R. A. Shagidullina

  DOI：10.1023/a:1020726010490

  日期：——

  The reaction of 4-nitrophenyl bis(chloromethyl)phosphinate with 2-dialkylaminomethylphenols in toluene solutions of polyethylene glycol 600 monolaurate was studied spectrophotometrically. The effect of structural features of the micellar system on the catalytic effect depends on the nucleophile hydrophobicity. Micellization of the nonionic surfactant was studied by dielectrometric titration and by the kinetic method. The aggregation numbers and the composition of detergent aggregates were determined.