2-ethoxyphenyl acetate | 78268-44-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: 2-ethoxyphenyl acetate
• 英文别名: 1-acetoxy-2-ethoxy-benzene；O'-Aethyl-O-acetyl-brenzcatechin；Essigsaeure-(2-aethoxy-phenylester)；1-Acetoxy-2-aethoxy-benzol；(2-Aethoxy-phenyl)-acetat；(2-ethoxyphenyl) acetate
• CAS: 78268-44-7
• 化学式: C₁₀H₁₂O₃
• 分子量: 180.203
• InChiKey: HLPBHWMIZHQNRC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-ethoxyphenyl acetate 生成 1-(3-Ethoxy-4-hydroxy-phenyl)-ethanone
  参考文献：
  名称：

  BOURGERY, G.;LACOUR, A.;MOINET, G.;POURRIAS, B.;RUCH, A. -M.

  摘要：

  DOI：
• 作为产物：
  描述：

  2-乙氧基苯甲醚 在 乙醚 、 邻二甲苯 作用下， 生成 2-ethoxyphenyl acetate
  参考文献：
  名称：

  Hirao, Nippon Kagaku Kaishi/Journal of the Chemical Society of Japan, 1932, vol. 53, p. 488,491

  摘要：

  DOI：

文献信息

• [EN] PROCESS FOR THE PREPARATION OF TAMSULOSIN<br/>[FR] PROCEDE DE PREPARATION DE TAMSULOSINE
  申请人：TORCAN CHEMICAL LTD

  公开号：WO2005051897A1

  公开（公告）日：2005-06-09

  There is provided a process for the preparation of tamsulosin of formula 5, involving a coupling reaction in the presence of an aluminum reagent between an ester of formula 2A and (R)-5-(2-amino)propyl-2-methoxy-benzenesulfonamide of formula 3 to yield tamsulosin amide, which is then reduced to yield tamsulosin.

  提供了一种制备化学式为5的坦索洛辛的方法，涉及在铝试剂存在下，在化学式2A的酯与化学式3的(R)-5-(2-氨基)丙基-2-甲氧基苯磺酰胺之间进行偶联反应，生成坦索洛辛酰胺，然后还原生成坦索洛辛。
• Breast cancer resistance protein (bcrp) inhibitor
  申请人：Yamazaki Ryuta

  公开号：US20060128636A1

  公开（公告）日：2006-06-15

  The invention provides a drug which inhibits BCRP. A breast cancer resistance protein inhibitor containing, as an active ingredient, a diphenylacrylonitrile derivative represented by the following formula (1): [wherein, each of 8 R's, which are the same or different from one another, represents a hydrogen atom, a hydroxyl group, a nitro group, an amino group, an acetylamino group (—NHCOCH 3 group); a cyano group (—CN group); a formyl group (—CHO group), —COOR 1 (R 1 is hydrogen or C1-C4 alkyl), —O(CH 2 ) n COOR 2 (n=1−7: R 2 is hydrogen or C1-C4 alkyl), —OOCCH 2 CH 2 COOR 3 (R 3 is hydrogen, C1-C4 alkyl, (Z)-2-(3,4-dimethoxy-phenyl)-3-(4-hydroxy-phenyl)-acrylonitrile, or glycopyranosyl), a C1-C8 alkoxy group, a C1-C4 alkyl group, a halogen atom, a C1-C4 alkoxy C1-C4 alkoxy C1-C4 alkoxy group, a C2-C8 acyloxy group, a C2-C8 halogenoacyloxy group, a methylenedioxy group, a trifluoromethyl group, a phosphate group (i.e., —OP(O) (OH) 2 ) or a salt thereof, a sulfate group (i.e., —OSO 3 H) or a salt thereof, a glycopyranosyl group or a salt thereof, a phosphate ester of a glycopyranosyl group or a salt of the ester, a sulfate ester of a glycopyranosyl group or a salt of the ester, or a piperidinopiperidinocarbonyloxy group], an ester thereof, or a salt thereof.

  本发明提供了一种抑制BCRP的药物。一种含有以下式（1）所表示的二苯乙烯腈衍生物作为活性成分的乳腺癌耐药蛋白抑制剂：[其中，8个R分别表示氢原子、羟基、硝基、氨基、乙酰氨基（—NHCOCH3基）、氰基（—CN基）、甲酰基（—CHO基）、—COOR1（R1为氢或C1-C4烷基）、—O（CH2）nCOOR2（n = 1-7：R2为氢或C1-C4烷基）、—OOCCH2CH2COOR3（R3为氢、C1-C4烷基、（Z）-2-（3,4-二甲氧基苯基）-3-（4-羟基苯基）-丙烯腈或葡萄糖基）、C1-C8烷氧基、C1-C4烷基、卤原子、C1-C4烷氧基C1-C4烷氧基C1-C4烷氧基、C2-C8酰氧基、C2-C8卤代酰氧基、亚甲二氧基基团、三氟甲基基团、磷酸酯基团（即—OP（O）（OH）2）或其盐、硫酸酯基团（即—OSO3H）或其盐、葡萄糖基或其盐、葡萄糖基的磷酸酯或酯的盐、葡萄糖基的硫酸酯或酯的盐，或者是它的酯或盐。
• Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme
  申请人：Iyengar Rajesh

  公开号：US20080064717A1

  公开（公告）日：2008-03-13

  The present invention relates to compounds of formula (I): wherein R 1 , R 3 , X, Q, Z, A, 9, m, and n are defined herein Pharmaceutical compositions and methods for treating DGAT-1 related diseases or conditions are also disclosed.

  本发明涉及式(I)的化合物：其中R1、R3、X、Q、Z、A、9、m和n在此定义。还公开了用于治疗DGAT-1相关疾病或病状的药物组合物和方法。
• CO ₂ ‐Promoted Direct Acylation of Amines and Phenols by the Activation of Inert Thioacid Salts
  作者：Huan Wang、Yudong Li、Shaoli Liu、Mohamed Makha、Jian‐Fei Bai、Yuehui Li

  DOI：10.1002/cssc.202200227

  日期：2022.5.20

  Greener acylation: A carbon dioxide-promoted acylation method is reported for the synthesis of amides and esters using non-traditional eco-friendly potassium thiocarboxylates. Compared to traditional methods, the developed procedure is not sensitive to either air or water and does not require metal catalysts, alkalis, or coupling reagents.

  更环保的酰化：据报道，一种二氧化碳促进的酰化方法使用非传统的环保硫代羧酸钾合成酰胺和酯。与传统方法相比，所开发的程序对空气或水都不敏感，并且不需要金属催化剂、碱或偶联剂。
• Sourdough compositions and methods for their preparation
  申请人：De Pauw Paul

  公开号：US10085457B2

  公开（公告）日：2018-10-02

  The present invention provides new flavors based on the fermentation of specific combinations of plants or plants extracts with specific combinations of microbial strains. More specifically sourdough products are provided with tea leaves or fractions thereof and fermented with the combination of strains of acetic acid bacteria and yeast in order to provide the new flavors.

  本发明提供了基于特定植物组合或植物提取物与特定微生物菌株组合发酵的新口味。更具体地说，酸面团产品中添加了茶叶或其馏分，并与醋酸菌和酵母菌的菌种组合一起发酵，以提供新的风味。