2-phenylbenzo[g]quinazolin-4(3H)-one | 22440-29-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-phenylbenzo[g]quinazolin-4(3H)-one
• 英文别名: 2-phenyl-3H-benzo[g]quinazolin-4-one
• CAS: 22440-29-5
• 化学式: C₁₈H₁₂N₂O
• 分子量: 272.306
• InChiKey: PAHPOGJQVHIJDO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  41.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-氨基-2-萘甲酸 在 (6,8,15,17-tetramethyldibenzo[b,i][1,4,8,11]-tetraazacyclotetradecinato)nickel(II) 、 N,N'-羰基二咪唑 、 sodium t-butanolate 作用下， 以 四氢呋喃 、 5,5-dimethyl-1,3-cyclohexadiene 为溶剂， 反应 44.0h， 生成 2-phenylbenzo[g]quinazolin-4(3H)-one
  参考文献：
  名称：

  邻位氨基苯甲酰胺与醇的镍催化脱氢偶联一锅梯级合成喹唑啉-4（3 H）-一。

  摘要：

  在本文中，我们报告了一种通过简单的Ni（II）催化邻氨基苯甲酰胺与醇的无受体脱氢偶联，一锅级联合成喹唑啉-4（3 H）-酮的通用，高效，环境友好的方法。催化剂[Ni（MeTAA）]，具有四氮杂大环配体（四甲基四氮杂[14]环戊烯（MeTAA））。从容易获得的苯甲醇和邻氨基苯甲酰胺开始，以高收率合成了多种取代的喹唑啉-4（3 H）-一。进行了几个受控反应以及氘标记研究，以建立反应的无受体脱氢性质。

  DOI：

  10.1021/acs.joc.7b00643

文献信息

• Cobalt complexes of redox noninnocent azo-aromatic pincers. Isolation, characterization, and application as catalysts for the synthesis of quinazolin-4(3<i>H</i>)-ones
  作者：Suman Sinha、Siuli Das、Rakesh Mondal、Sutanuva Mandal、Nanda D. Paul

  DOI：10.1039/d0dt00394h

  日期：——

  9-bis(phenyldiazo)-1,10-phenanthroline (L2) ligands produced two new mononuclear five-coordinate cobalt(II)-complexes 1b and 2 respectively. In complex 1a and 1b, the ligands L1a and L1b are coordinated to the cobalt(II)-center in a tridentate mode utilizing all of its nitrogen donor sites while in complex 2 one of the azo-donor sites of the ligand L2 remain pendant. All these complexes were characterized using available

  在这里我们报告了氧化还原非纯芳基偶氮配体2-（苯基偶氮）-1,10-菲咯啉（L 1a），2-（4-氯苯基偶氮）-1的三种新型钴（II）配合物的合成，表征和催化应用分别是，10-菲咯啉（L 1b）和2,9-双（苯基重氮）-1，10-菲咯啉（L 2）。的反应大号1A用Co II氯2 ·6H 2 O产生一个μ二氯桥接的双核钴（II） -配合物[CO II 2（大号1A）2氯2 ]（1a中），而与2-（4-氯苯基）偶氮-1,10-菲咯啉（L 1b）和2,9-双（苯基重氮）-1,10-菲咯啉（L 2）配体进行相同反应时，会产生两个新的单核五配位钴（II）配合物1b和2。在配合物1a和1b中，配体L 1a和L 1b利用其所有氮供体位点以三齿模式配位到钴（II）中心，而在配合物2中，配体L 2的偶氮供体位点之一保持吊坠。使用可用的光谱技术和DFT研究对所有这些复合物进行了表征。我们进一步探讨了这些配合物
• <i>ortho</i>-Naphthoquinone-catalyzed aerobic oxidation of amines to fused pyrimidin-4(3<i>H</i>)-ones: a convergent synthetic route to bouchardatine and sildenafil
  作者：Kyeongha Kim、Hun Young Kim、Kyungsoo Oh

  DOI：10.1039/d0ra06820a

  日期：——

  A facile access to fused pyrimidin-4(3H)-one derivatives has been established by using the metal-free ortho-naphthoquinone-catalyzed aerobic cross-coupling reactions of amines. The utilization of two readily available amines allowed a direct coupling strategy to quinazolinone natural product, bouchardatine, as well as sildenafil (Viagra™) in a highly convergent manner.

  通过使用无金属邻萘醌催化的胺有氧交叉偶联反应，已经建立了一种容易获得稠合 pyrimidin-4(3 H )-one 衍生物的方法。利用两种容易获得的胺，可以以高度收敛的方式直接偶联喹唑啉酮天然产物布沙达汀和西地那非 (Viagra™)。
• Fiber-Type Transitions and Satellite Cell Activation in Low-Frequency-Stimulated Muscles of Young and Aging Rats
  作者：C. T. Putman、K. R. Sultan、T. Wassmer、J. A. Bamford、D. Skorjanc、D. Pette

  DOI：10.1093/gerona/56.12.b510

  日期：2001.12.1

  We examined satellite cell content and the activity of satellite cell progeny in tibialis anterior muscles of young (15 weeks) and aging (101 weeks) Brown Norway (BN) rats. after they were exposed for 50 days to a standardized and highly reproducible regime of chronic low-frequency electrical stimulation. Chronic low-frequency electrical stimulation was successful in inducing fast-to-slow fiber-type transformation, characterized by a 2.3-fold increase in the proportion of IIA fibers and fourfold and sevenfold decreases in the proportion of IID/X and IIB fibers in both young and aging BN rats. These changes were accompanied by a twofold increase in the satellite cell content in both the young and aging groups: satellite cell content reached a level that was significantly higher in the young group (p < .04). The total muscle precursor cell content (i.e., satellite cells plus progeny), however, did not differ between groups, because there was a greater number of satellite cell progeny passing through the proliferative and differentiative compartments of the aging group. The resulting 1.5-fold increase in myonuclear content was similar in the young and aging groups. We conclude that satellite cells and satellite cell progeny of aging BN rats possess an unaltered capacity to contribute to the adaptive response.
• Mehta; Patel, Indian Journal of Chemistry, 1968, vol. 6, p. 294,296
  作者：Mehta、Patel

  DOI：——

  日期：——