N-[di(tetradecoxy)phosphorylmethyl]-N-prop-2-enylprop-2-en-1-amine | 222631-05-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: N-[di(tetradecoxy)phosphorylmethyl]-N-prop-2-enylprop-2-en-1-amine
• CAS: 222631-05-2
• 化学式: C₃₅H₇₀NO₃P
• 分子量: 583.919
• InChiKey: VLMIKLMOVXEFBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.2
• 重原子数：
  40
• 可旋转键数：
  34
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-[di(tetradecoxy)phosphorylmethyl]-N-prop-2-enylprop-2-en-1-amine 在 bis(dibenzylideneacetone)-palladium⁽⁰⁾ 硫代水杨酸 、 N,N-二异丙基乙胺 、 丁基二苯基膦 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 72.0h， 生成 guanidinomethylphosphonic acid ditetradecyl ester
  参考文献：
  名称：

  Phosphonolipids as non-viral vectors for gene therapy

  摘要：

  Several phosphonates with two fatty chains and different polar heads were synthesized and evaluated for their potential to transfer DNA into epithelial (COS-7) and hematopoietic (K562) cell lines, and compared to commercially available references. In both cases, ammonium-phosphonates were particularly efficient. (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(99)80017-8
• 作为产物：
  描述：

  聚合甲醛 、 dimyristyl phosphite 、 二烯丙基胺 以 四氢呋喃 、 水 为溶剂， 反应 18.0h， 生成 N-[di(tetradecoxy)phosphorylmethyl]-N-prop-2-enylprop-2-en-1-amine
  参考文献：
  名称：

  Phosphonolipids as non-viral vectors for gene therapy

  摘要：

  Several phosphonates with two fatty chains and different polar heads were synthesized and evaluated for their potential to transfer DNA into epithelial (COS-7) and hematopoietic (K562) cell lines, and compared to commercially available references. In both cases, ammonium-phosphonates were particularly efficient. (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(99)80017-8

文献信息

• Phosphonolipids as non-viral vectors for gene therapy
  作者：Virginie Floch、Gwénaëlle Le Bolc'h、Christine Gable-Guillaume、Nathalie Le Bris、Jean-Jacques Yaouanc、Hervé des Abbayes、Claude Férec、Jean-Claude Clément

  DOI：10.1016/s0223-5234(99)80017-8

  日期：1998.12

  Several phosphonates with two fatty chains and different polar heads were synthesized and evaluated for their potential to transfer DNA into epithelial (COS-7) and hematopoietic (K562) cell lines, and compared to commercially available references. In both cases, ammonium-phosphonates were particularly efficient. (C) Elsevier, Paris.