<3S(3α,3aα,9aα,9bβ)>-7-methylene-3a,6,6-trimethyldodecahydro-1H-benzinden-3-ol | 40401-20-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: <3S(3α,3aα,9aα,9bβ)>-7-methylene-3a,6,6-trimethyldodecahydro-1H-benzinden-3-ol
• CAS: 40401-20-5
• 化学式: C₁₇H₂₈O
• 分子量: 248.409
• InChiKey: HKMSOXFYCYBRLW-MDLJMBGESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.17
• 重原子数：
  18.0
• 可旋转键数：
  0.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  20.23
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  (3S,3aS,5aS,6R,9aS,9bS)-6-Bromomethyl-3a,6-dimethyl-7-methylene-dodecahydro-cyclopenta[a]naphthalen-3-ol 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 生成 <3S(3α,3aα,9aα,9bβ)>-7-methylene-3a,6,6-trimethyldodecahydro-1H-benzinden-3-ol
  参考文献：
  名称：

  雄激素合成代谢类固醇的合成。

  摘要：

  DOI：

  10.1021/jm00259a028

文献信息

• Antiandrogenic activity of a series of des-A-steroid derivatives
  作者：Hilda Morales-Alanis、Marie Josephe Brienne、Jean Jacques、Marie M. Bouton、Lucien Nedelec、Vesperto Torelli、Colette Tournemine

  DOI：10.1021/jm00150a009

  日期：1985.12

  In the search for new antiandrogens, a number of des-A-steroids were prepared by condensation of Grignard reagents with lactone 3. From the resulting key intermediates 5, various structural modifications were performed such as the introduction of an additional unsaturation to afford dienones 8 and aromatic derivatives 10 or the introduction of an alkyl substituent mostly in position 10 (11-13) but also in some cases in position 16 (22). In addition, 13-ethyl analogues were also prepared from lactone 4. The relative binding affinities (RBAs) for the androgen receptor of these compounds were determined under various conditions. Some compounds exhibit a capacity to interact with the receptor comparable to that of testosterone. One of the most potent compounds is 17beta-hydroxy-des-A-androsta-9,11-dien-5-one (8b), RBA value 73% of that of testosterone. More interestingly, several compounds were found to have an antiandrogenic profile in vitro and in vivo. One of the most effective compounds is 10-ethyl-17beta-hydroxy-des-A-estra-9-en-5-one (5c), which exhibits a strong local antiandrogenic activity in hamsters, without any significant systemic antiandrogenic effects. The corresponding 17beta-acetyl derivative (RU 38882) has been selected for extended pharmacological studies.