[(2R,5R,6R)-7-(tert-Butyl-dimethyl-silanyloxy)-2,6-dimethyl-3-methylene-5-trimethylsilanyloxy-heptyloxymethyl]-benzene | 217964-67-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(2R,5R,6R)-7-(tert-Butyl-dimethyl-silanyloxy)-2,6-dimethyl-3-methylene-5-trimethylsilanyloxy-heptyloxymethyl]-benzene
• CAS: 217964-67-5
• 化学式: C₂₆H₄₈O₃Si₂
• 分子量: 464.836
• InChiKey: RUTOHQYITALYQQ-JBRSBNLGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.66
• 重原子数：
  31.0
• 可旋转键数：
  13.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  27.69
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  [(2R,5R,6R)-7-(tert-Butyl-dimethyl-silanyloxy)-2,6-dimethyl-3-methylene-5-trimethylsilanyloxy-heptyloxymethyl]-benzene 在 camphor-10-sulfonic acid 、 四丁基氟化铵 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 (2S,4R,5R)-2-(4-methoxyphenyl)-5-methyl-4-[(3R)-3-methyl-2-methylidene-4-phenylmethoxybutyl]-1,3-dioxane
  参考文献：
  名称：

  On 1,4-diastereoselectivity in the chiral allylsilane addition to chiral α-substituted aldehydes

  摘要：

  Chiral allylsilane 2 reacted with chiral alpha-substituted aldehydes to afford the corresponding 1,4-syn-products with good diastereoselectivities. The best selectivities are observed when the reactions are carried out by transmetallation of allylsilane using Tin (IV) chloride in CH2Cl2, at -78 degrees C, before addition of the aldehydes. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)01066-1
• 作为产物：
  描述：

  叔丁基二甲基氯硅烷 在 四氯化锡 作用下， 反应 1.5h， 生成 [(2R,5R,6R)-7-(tert-Butyl-dimethyl-silanyloxy)-2,6-dimethyl-3-methylene-5-trimethylsilanyloxy-heptyloxymethyl]-benzene
  参考文献：
  名称：

  On 1,4-diastereoselectivity in the chiral allylsilane addition to chiral α-substituted aldehydes

  摘要：

  Chiral allylsilane 2 reacted with chiral alpha-substituted aldehydes to afford the corresponding 1,4-syn-products with good diastereoselectivities. The best selectivities are observed when the reactions are carried out by transmetallation of allylsilane using Tin (IV) chloride in CH2Cl2, at -78 degrees C, before addition of the aldehydes. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)01066-1