4-[5-(4-phenoxyphenoxy)pentoxy]-7H-furo[3,2-g][1]benzopyran-7-on | 882686-76-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 4-[5-(4-phenoxyphenoxy)pentoxy]-7H-furo[3,2-g][1]benzopyran-7-on
• 英文别名: 4-[5-(4-Phenoxyphenoxy)pentoxy]furo[3,2-g]chromen-7-one
• CAS: 882686-76-2
• 化学式: C₂₈H₂₄O₆
• 分子量: 456.495
• InChiKey: NQMOZISGKMVCMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  34
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  67.1
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• 5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated Kv1.3 potassium channel
  申请人：Wulff Heike

  公开号：US20060079535A1

  公开（公告）日：2006-04-13

  Compositions of matter comprising 5-phenoxyalkoxypsoralen compounds and their method of synthesis and use. The compounds are useable to treat diseases or disorders in human or animal subjects, including autoimmune diseases. The compounds inhibit potassium channels, including the Kv1.3 channel and at least some of the therapeutic effects of such compounds may be due at least in part to potassium channel inhibition. In some embodiments, the compounds are more selective for certain potassium channels (e.g., Kv1.3 channels) than other potassium channels (e.g., Kv1.5 channels).

  包括5-苯氧烷氧基橙光素化合物的物质组合物及其合成和使用方法。这些化合物可用于治疗人类或动物主体的疾病或紊乱，包括自身免疫疾病。这些化合物抑制钾通道，包括Kv1.3通道，这些化合物的至少一些治疗效果可能至少部分归因于钾通道的抑制。在某些实施例中，这些化合物对某些钾通道（例如Kv1.3通道）的选择性更高于其他钾通道（例如Kv1.5通道）。
• 5-PHENOXYALKOXYPSORALENS AND METHODS FOR SELECTIVE INHIBITION OF THE VOLTAGE GATED Kv1.3 POTASSIUM CHANNEL
  申请人：Wulff Heike

  公开号：US20100121059A1

  公开（公告）日：2010-05-13

  Compositions of matter comprising 5-phenoxyalkoxypsoralen compounds and their method of synthesis and use. The compounds are useable to treat diseases or disorders in human or animal subjects, including autoimmune diseases. The compounds inhibit potassium channels, including the Kv1.3 channel and at least some of the therapeutic effects of such compounds may be due at least in part to potassium channel inhibition. In some embodiments, the compounds are more selective for certain potassium channels (e.g., Kv1.3 channels) than other potassium channels (e.g., Kv1.5 channels).

  物质组合物包括5-苯氧基烷氧基紫檀酮化合物及其合成和使用方法。这些化合物可用于治疗人或动物主体的疾病或障碍，包括自身免疫性疾病。这些化合物抑制钾通道，包括Kv1.3通道，这些化合物的至少一些治疗效果可能部分归因于钾通道抑制作用。在某些实施例中，这些化合物对某些钾通道（例如Kv1.3通道）的选择性更高，而对其他钾通道（例如Kv1.5通道）的选择性较低。
• 5-PHENOXYALKOXYPSORALENS AND METHODS FOR SELECTIVE INHIBITION OF THE VOLTAGE GATED KV1.3 POTASSIUM CHANNEL
  申请人：The Regents of the University of California

  公开号：EP1796674B1

  公开（公告）日：2016-02-03
• US7557138B2
  申请人：——

  公开号：US7557138B2

  公开（公告）日：2009-07-07
• US8067460B2
  申请人：——

  公开号：US8067460B2

  公开（公告）日：2011-11-29