2-[α-(p-iodophenyl)-α-hydroxymethyl]furan | 250695-02-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[α-(p-iodophenyl)-α-hydroxymethyl]furan
• 英文别名: 2-[α-hydroxy-α-(4-iodophenyl)]methylfuran；Furan-2-yl-(4-iodophenyl)methanol
• CAS: 250695-02-4
• 化学式: C₁₁H₉IO₂
• 分子量: 300.096
• InChiKey: MUZNIBCXIDPBAD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  33.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-[α-(p-iodophenyl)-α-hydroxymethyl]furan 在 三氯化铝 、 三氟化硼乙醚 作用下， 以 二氯甲烷 为溶剂， 反应 4.5h， 生成 (4-iodophenyl)[5-(p-toluoyl)furan-2-yl][5-(p-toluoyl)pyrrol-2-yl]methane
  参考文献：
  名称：

  Rational Synthesis of Trans-Substituted Porphyrin Building Blocks Containing One Sulfur or Oxygen Atom in Place of Nitrogen at a Designated Site

  摘要：

  The use of heteroatom-substituted porphyrins in bioorganic and materials chemistry requires the ability to position a variety of substituents in a controlled manner about the porphyrin periphery. We describe a rational route to trans-AB(2)C-type porphyrins bearing one oxygen atom (N3O) or one sulfur atom (NBS) in a designated location in the porphyrin core. The synthesis involved four stages: (1) Acid-catalyzed condensation of a furyl- or thienylcarbinol in excess pyrrole afforded the aryl-substituted furyl- or thienylpyrromethane in high yield. (2) Treatment of the furyl- or thienylpyrromethane with an acid chloride catalyzed by SnCl4 or AlCl3 afforded the corresponding diketo product. (3) Reduction with NaBH4 in alcoholic solvents gave the furyl- or thienylpyrromethanediols. (4) Reaction of a furylpyrromethanediol, thienylpyrromethanediol, or dipyrromethanediol with a dipyrromethane in a one-flask process of condensation followed by oxidation gave the corresponding porphyrin. Reaction conditions previously identified to minimize scrambling in a dipyrromethane-aldehyde condensation were found to be effective in this application. Thus, reaction with 10 mM reactants in acetonitrile at 0 degrees C containing BF3 . Et2O and NH4Cl followed by oxidation with DDQ resulted in the desired porphyrin(10-20% yields) without acidolysis. In this manner, N3O-, N3S-, or Na-porphyrins bearing 5-(p-iodophenyl), 15-[4-(2-(trimethylsilyl)ethynyl)phenyl], and 10,20-di-p-tolyl groups have been made. This set of trans-substituted porphyrin building blacks is expected to be useful in the synthesis of biomimetic energy transduction systems.

  DOI：

  10.1021/jo9909305
• 作为产物：
  描述：

  2-(4-iodobenzoyl)furan 在 sodium tetrahydroborate 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 0.17h， 以99%的产率得到2-[α-(p-iodophenyl)-α-hydroxymethyl]furan
  参考文献：
  名称：

  Rational Synthesis of Trans-Substituted Porphyrin Building Blocks Containing One Sulfur or Oxygen Atom in Place of Nitrogen at a Designated Site

  摘要：

  The use of heteroatom-substituted porphyrins in bioorganic and materials chemistry requires the ability to position a variety of substituents in a controlled manner about the porphyrin periphery. We describe a rational route to trans-AB(2)C-type porphyrins bearing one oxygen atom (N3O) or one sulfur atom (NBS) in a designated location in the porphyrin core. The synthesis involved four stages: (1) Acid-catalyzed condensation of a furyl- or thienylcarbinol in excess pyrrole afforded the aryl-substituted furyl- or thienylpyrromethane in high yield. (2) Treatment of the furyl- or thienylpyrromethane with an acid chloride catalyzed by SnCl4 or AlCl3 afforded the corresponding diketo product. (3) Reduction with NaBH4 in alcoholic solvents gave the furyl- or thienylpyrromethanediols. (4) Reaction of a furylpyrromethanediol, thienylpyrromethanediol, or dipyrromethanediol with a dipyrromethane in a one-flask process of condensation followed by oxidation gave the corresponding porphyrin. Reaction conditions previously identified to minimize scrambling in a dipyrromethane-aldehyde condensation were found to be effective in this application. Thus, reaction with 10 mM reactants in acetonitrile at 0 degrees C containing BF3 . Et2O and NH4Cl followed by oxidation with DDQ resulted in the desired porphyrin(10-20% yields) without acidolysis. In this manner, N3O-, N3S-, or Na-porphyrins bearing 5-(p-iodophenyl), 15-[4-(2-(trimethylsilyl)ethynyl)phenyl], and 10,20-di-p-tolyl groups have been made. This set of trans-substituted porphyrin building blacks is expected to be useful in the synthesis of biomimetic energy transduction systems.

  DOI：

  10.1021/jo9909305

文献信息

• Catalytic and enantioselective oxa-Piancatelli reaction using a chiral vanadium complex
  作者：Lukas Schober、Makoto Sako、Shinobu Takizawa、Harald Gröger、Hiroaki Sasai

  DOI：10.1039/d0cc02621b

  日期：——

  An enantioselective oxa-Piancatelli reaction was established for the first time using a chiral vanadium(V) catalyst. The dual Brønsted and Lewis acid properties of the vanadium catalyst afforded 4-hydroxycyclopent-2-enone derivatives in up to 90% yields and with 93 : 7 enantiomeric ratios, as well as >20 : 1 diastereomeric ratios.

  使用手性钒（V）催化剂首次建立了对映选择性的oxa-Piancatelli反应。钒催化剂的布朗斯台德和路易斯酸的双重性质以高达90％的收率和93：7对映体比率以及> 20：1非对映体比率提供了4-羟基环戊-2-烯酮衍生物。
• One-Flask Synthesis of Mono- and Trifunctionalized 21-Thia and 21-Oxaporphyrin Building Blocks and Their Application in the Synthesis of Covalent and Noncovalent Unsymmetrical Porphyrin Arrays
  作者：Iti Gupta、Mangalampalli Ravikanth

  DOI：10.1021/jo040178u

  日期：2004.10.1

  symmetrical phenylethyne bridged dimer containing two N3S cores. A preliminary photophysical study on these dimers indicated a possibility of energy transfer from one subunit to another. We also demonstrated the use of trifunctionalized porphyrins in the synthesis of two noncovalent unsymmetrical porphyrin tetramers containing one N3S and three N4 porphyrin subunits.

  已开发出一种快速合成路线，可使用简单的前体例如2 [α-（芳基）-α-羟甲基]噻吩（噻吩单醇）和2 [α- （芳基）-α-羟甲基]呋喃（呋喃单醇）。在卟啉形成条件下，将一当量的噻吩或呋喃一元醇与两当量的芳基醛和三当量的吡咯缩合，然后进行柱色谱分离，得到官能化的21-硫杂或21-氧杂卟啉。为了合成单官能化的卟啉，使用了含有官能化的芳基的单醇。官能化的醛用于合成三官能化的卟啉。一元醇方法用途广泛，可用于合成含有官能团（如碘苯基，乙炔基苯基，羟苯基，溴苯基和吡啶基）的单官能和三官能化的21-硫杂和21-氧杂卟啉。含碘苯基和乙炔基苯基的单官能化卟啉结构单元进一步用于合成四个不对称的共价卟啉二聚体，其中包含两个不同的卟啉核心，例如N经由二芳基乙炔基桥接的3 S N 4，N 3 O-N 4和N 3 S-N 3 O和包含两个N 3 S核的一个对称的苯基乙炔桥接的二聚体。对这些二聚体的初步光物理研究表明，