1,7-bis(3,4,5-trihydroxyphenyl)-3-hydroxy-1,3,6-heptatriene-5-one | 471909-78-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 1,7-bis(3,4,5-trihydroxyphenyl)-3-hydroxy-1,3,6-heptatriene-5-one
• 英文别名: (1E,4Z,6E)-5-hydroxy-1,7-bis(3,4,5-trihydroxyphenyl)hepta-1,4,6-trien-3-one
• CAS: 471909-78-1
• 化学式: C₁₉H₁₆O₈
• 分子量: 372.331
• InChiKey: SUBARYCCAIUSLH-QURVRLOFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  159
• 氢给体数：
  7
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  以 水 为溶剂， 反应 12.0h， 以90%的产率得到1,7-bis(3,4,5-trihydroxyphenyl)-3-hydroxy-1,3,6-heptatriene-5-one
  参考文献：
  名称：

  一种人工合成姜黄素及其衍生物的方法

  摘要：

  本发明公开一种人工合成姜黄素及其衍生物的方法。该方法以乙酰丙酮钙为乙酰丙酮供源，经与相应的苯甲醛衍生物进行克莱森‑施密特酯缩合反应并在脱水剂硼酸三正丁酯催化下脱水后得到产物中间体(Ⅰ)姜黄素钙盐；然后中间体(Ⅰ)经一锅法水解得粗品，粗品提纯后得到最终产物姜黄素及其衍生物。与乙酰丙酮硼酸络合物法相比，本发明使用乙酰丙酮钙可以使得反应过程中乙酰丙酮基活性位点更为精确、活化，从而减少副产物的生成，提高姜黄素及其衍生物的产率。

  公开号：

  CN106748705B

文献信息

• Novel polyhydroxy curcumins having antioxidant activity
  申请人：——

  公开号：US20030216600A1

  公开（公告）日：2003-11-20

  This invention relates to novel polyhydroxy curcumins of the formula (I), wherein R and R 1 may be same or different and are selected from H, OH and OCH 3 . This invention also includes a process for synthesising the above polyhydroxy curcumins by reacting substituted aromatic alhehydes with a diketone in the presence of boron oxide, alkyl borate and a primary or secondary amine catalyst. If desired, the resulting compounds can be deprotected by known means. These compounds are used as anti-oxidants.
• US6900356B2
  申请人：——

  公开号：US6900356B2

  公开（公告）日：2005-05-31
• [EN] NOVEL POLYHYDROXY CURCUMINS HAVING ANTIOXIDANT ACTIVITY<br/>[FR] NOUVELLES POLYHYDROXYCURCUMINES A EFFET ANTIOXYDANT
  申请人：LAILA IMPEX

  公开号：WO2002083614A1

  公开（公告）日：2002-10-24

  This invention relates to novel polyhydroxy curcumins of the formula (I), wherein R and R1 may be same or different and are selected from H, OH and OCH¿3?. This invention also includes a process for synthesising the above polyhydroxy curcumins by reacting substituted aromatic alhehydes with a diketone in the presence of boron oxide, alkyl borate and a primary or secondary amine catalyst. If desired, the resulting compounds can be deprotected by known means. These compounds are used as anti-oxidants.