3-{4-[3-((1R,4R)-5-cyclopropylmethyl-2,5-diaza-bicyclo[2.2.1]hept-2-yl)-propyl]-benzyl}-2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine | 1197878-82-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 3-{4-[3-((1R,4R)-5-cyclopropylmethyl-2,5-diaza-bicyclo[2.2.1]hept-2-yl)-propyl]-benzyl}-2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine
• 英文别名: 3-[[4-[3-[(1R,4R)-5-(cyclopropylmethyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]propyl]phenyl]methyl]-2-ethyl-5,7-dimethylimidazo[4,5-b]pyridine
• CAS: 1197878-82-2
• 化学式: C₂₉H₃₉N₅
• 分子量: 457.662
• InChiKey: BJANHIAZXONOHC-CLJLJLNGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  37.2
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• IMIDAZO PYRIDINE DERIVATIVES
  申请人：Taracido Ivan Cornella

  公开号：US20090291942A1

  公开（公告）日：2009-11-26

  The invention relates to novel imidazopyridine derivatives and to their use in the treatment of diseases and disorders which may e.g. involve angiogenesis and/or pain, including autoimmune and inflammatory diseases.

  这项发明涉及新型咪唑吡啶衍生物及其在治疗可能涉及血管生成和/或疼痛的疾病和紊乱中的应用，包括自身免疫和炎症性疾病。
• COMPOUNDS FOR USE IN GASTRIC COMPLICATION
  申请人：Christ Andreas

  公开号：US20150216867A1

  公开（公告）日：2015-08-06

  The present invention relates to the use of low molecular weight (lmw) compounds, especially lmw compounds with GPR4-affinity, in the treatment of diseases and disorders which includes gastroesophageal reflux disease (GERD), and/or non-erosive reflux disease (NERD) and the like.

  本发明涉及低分子量化合物（LMW），特别是具有GPR4亲和力的LMW化合物在治疗疾病和疾病中的应用，包括胃食管反流病（GERD）和/或非侵蚀性反流病（NERD）等。
• [EN] IMIDAZOPYRIDINE DERIVATIVES AS GPR4 RECEPTOR MODULATORS<br/>[FR] DÉRIVÉS IMIDAZOPYRIDINE COMME MODULATEURS DU RÉCEPTEUR GPR4
  申请人：NOVARTIS AG

  公开号：WO2009144201A1

  公开（公告）日：2009-12-03

  The invention relates to novel imidazopyridine derivatives and to their use in the treatment of diseases and disorders which may e.g. involve angiogenesis and/or pain, including autoimmune and inflammatory diseases.