1-methyl-4-(4-nitrophenyl)pyrrolidin-2-one | 1082203-71-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-methyl-4-(4-nitrophenyl)pyrrolidin-2-one
• CAS: 1082203-71-1
• 化学式: C₁₁H₁₂N₂O₃
• 分子量: 220.228
• InChiKey: ODDIRNSGUQLFFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  66.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-nitrobenzenediazonium tetrafluoroborate 在 palladium diacetate 、 sodium hydride 、 三氟乙酸 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 、 乙腈 、 mineral oil 为溶剂， 反应 9.25h， 生成 1-methyl-4-(4-nitrophenyl)pyrrolidin-2-one
  参考文献：
  名称：

  TRICYCLIC COMPOUNDS

  摘要：

  The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof. The present application also describes pharmaceutical composition comprising a compound of Formula (I), and pharmaceutically acceptable salts thereof, and methods of using the compounds and compositions for treating diseases such as cancer.

  公开号：

  WO2024107393A1

文献信息

• Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase
  作者：Jeffrey Y. Melamed、Melissa S. Egbertson、Sandor Varga、Joseph P. Vacca、Greg Moyer、Lori Gabryelski、Peter J. Felock、Kara A. Stillmock、Marc V. Witmer、William Schleif、Daria J. Hazuda、Yvonne Leonard、Lixia Jin、Joan D. Ellis、Steven D. Young

  DOI：10.1016/j.bmcl.2008.08.038

  日期：2008.10

  HIV-1 integrase catalyzes the insertion of viral DNA into the genome of the host cell. Integrase inhibitor N-(4-fluorobenzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamide selectively inhibits the strand transfer process of integration. 4-Substituted pyrrolidinones possessing various groups on the pyrrolidinone nitrogen were introduced at the 5-position of the naphthyridine scaffold. These analogs exhibit excellent activity against viral replication in a cell-based assay. The preparation of these compounds was enabled by a three-step, two-pot reaction sequence from a common butenolide intermediate. (c) 2008 Elsevier Ltd. All rights reserved.