compound 119 | 842127-99-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: compound 119
• 英文别名: N-[[3-[5-[3-(2-aminopyrimidin-4-yl)anilino]triazolo[4,5-d]pyrimidin-3-yl]phenyl]methyl]cyclopropanecarboxamide
• CAS: 842127-99-5
• 化学式: C₂₅H₂₂N₁₀O
• 分子量: 478.516
• InChiKey: QTICHSHQWLMGCX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  36
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  149
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• Differentiation of pluripotent stem cells
  申请人：Janssen Biotech, Inc.

  公开号：US10233421B2

  公开（公告）日：2019-03-19

  The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.

  本发明涉及多能干细胞的分化方法。特别是，本发明涉及将多能干细胞分化成表达明确内胚层特征标记的细胞的方法和组合物，包括在含有足量 GDF-8 的培养基中培养多能干细胞，使多能干细胞分化成表达明确内胚层特征标记的细胞。
• Methods for making definitive endoderm using at least GDF-8
  申请人：Janssen Biotech, Inc.

  公开号：US10351820B2

  公开（公告）日：2019-07-16

  The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.

  本发明涉及多能干细胞的分化方法。特别是，本发明涉及将多能干细胞分化成表达明确内胚层特征标记的细胞的方法和组合物，包括在含有足量 GDF-8 的培养基中培养多能干细胞，使多能干细胞分化成表达明确内胚层特征标记的细胞。
• DIFFERENTIATION OF PLURIPOTENT STEM CELLS
  申请人：Janssen Biotech, Inc.

  公开号：EP2310492B1

  公开（公告）日：2015-07-22
• Differentiation of Pluripotent Stem Cells
  申请人：Davis Janet

  公开号：US20100015711A1

  公开（公告）日：2010-01-21

  The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.
• US9593305B2
  申请人：——

  公开号：US9593305B2

  公开（公告）日：2017-03-14