4-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-butyric acid methyl ester | 65562-95-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 4-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-butyric acid methyl ester
• 英文别名: methyl 4-(2-oxo-3H-benzimidazol-1-yl)butanoate
• CAS: 65562-95-0
• 化学式: C₁₂H₁₄N₂O₃
• 分子量: 234.255
• InChiKey: ASSRJYCTBUDHHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• PROCESSES FOR MAKING ZILPATEROL AND SALTS THEREOF
  申请人：Dubuis Stephane

  公开号：US20100121050A1

  公开（公告）日：2010-05-13

  This invention generally relates to processes for making zilpaterol and salts thereof, as well as processes for making intermediates that, inter alia, may be used to make zilpaterol and salts thereof. The zilpaterol and salts prepared in accordance with this invention can be used to increase the rate of weight gain, improve feed efficiency, and/or increase carcass leanness in livestock, poultry, and fish.

  本发明通常涉及制备奥美拉唑及其盐的过程，以及制备中间体的过程，其中中间体可以用于制备奥美拉唑及其盐等。根据本发明制备的奥美拉唑和盐可用于提高家畜、家禽和鱼类的体重增长速度，改善饲料效率和/或增加胴体瘦肉率。
• Enantioselective synthesis of 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo[4,5,1-JK][1]-benzazepin-2[1H]-one and zilpaterol
  申请人：Almena-Perea Juan Jose

  公开号：US20100173892A1

  公开（公告）日：2010-07-08

  This invention relates to a process for the hydrogenation of a ketooxime to selectively form an aminoalcohol stereoisomer, and, in particular, to a process for the hydrogenation of 4,5-dihydro-imidazo[4,5,1-jk][1]benzazepin-2,6,7[1H]-trione-6-oxime or a salt thereof to selectively form a stereoisomer of 6-amino-7-hydroxy-4,5,6, 7-tetrahydro-imidazo[4,5,1-jk][1]-benzazepin-2[1H]-one or a salt thereof. This invention also relates to the use of the 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo[4,5,1-jk][1]-benzazepin-2[1H]-one hydrogenation product or a salt thereof to selectively make a stereoisomer of zilpaterol or a salt thereof, as well as the use of such a zilpaterol stereoisomer or salt in methods of treatment and medicaments for animals.

  本发明涉及一种氢化酮肟的方法，以选择性地形成氨基醇立体异构体，特别是涉及一种对4,5-二氢咪唑[4,5,1-jk][1]苯并氮杂环-2,6,7[1H]-三酮-6-肟或其盐进行氢化的方法，以选择性地形成6-氨基-7-羟基-4,5,6,7-四氢咪唑[4,5,1-jk][1]-苯并氮杂环-2[1H]-酮或其盐的立体异构体。本发明还涉及使用6-氨基-7-羟基-4,5,6,7-四氢咪唑[4,5,1-jk][1]-苯并氮杂环-2[1H]-酮氢化产物或其盐选择性地制备一种齐帕特罗尔的立体异构体或其盐，以及使用这种齐帕特罗尔立体异构体或其盐在动物治疗和药物中的方法。
• BICYCLIC ANILIDE SPIROHYDANTOIN CGRP RECEPTOR ANTAGONISTS
  申请人：Merck & Co. Inc.

  公开号：EP1608627B1

  公开（公告）日：2008-05-07
• US4161603A
  申请人：——

  公开号：US4161603A

  公开（公告）日：1979-07-17
• US7202251B2
  申请人：——

  公开号：US7202251B2

  公开（公告）日：2007-04-10