3-(diethyl-methyl-silanyl)-propionic acid | 119301-90-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-(diethyl-methyl-silanyl)-propionic acid
• 英文别名: 3-(Diaethyl-methyl-silyl)-propionsaeure；3-(Diethylmethyl-silyl)propionic acid；3-[diethyl(methyl)silyl]propanoic acid
• CAS: 119301-90-5
• 化学式: C₈H₁₈O₂Si
• mdl: MFCD00461907
• 分子量: 174.315
• InChiKey: NVGJOMICHLNFKX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.36
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(diethyl-methyl-silanyl)-propionic acid 、 triethylsilyl propionate 生成 3-(diethyl-methyl-silanyl)-propionic acid triethylsilanyl ester
  参考文献：
  名称：

  与镓基修复材料相关的牙科术后敏感性

  摘要：

  Introduction This study forms part of a 2-year longitudinal clinical trial to compare the performance of a gallium-based restorative material (Galloy) with a high copper, mercury based (Dispersalloy) control material.Method Following Ethical Committee approval, 25 galley restorations and 25 Dispersalloy controls were placed in 14 adult patients, by a single operator. The cavities were of moderate size, indicating the use of amalgam as the restorative material. All restorations were polished within 1 week of placement, photographed and a silicone impression of the tooth and restoration recorded. In addition, a visual analogue scale (VAS), indicating the extent of any post-operative sensitivity, was completed by each patient for each restoration, immediately prior to polishing. A score of 0 indicated no sensitivity, while a score of 10 indicated the greatest possible sensitivity. At B-month recall, the VAS scores, silicone impressions and photographs were repeated.Results The mean sensitivity scores for the galley and Dispersalloy restorations at 1 week were 5.1 (+/-3.4) and 1.0 (+/-1.5), respectively and at 6 months, 1.8 (+/-3.0) and 0.2 (+/-0.1) respectively. The differences between these means at 1 week and at 6 months were significant (P < 0.01).Conclusion Galley restorations were associated with a much greater severity of post-operative sensitivity than Dispersalloy restorations.

  DOI：

  10.1038/sj.bdj.4800755a
• 作为产物：
  描述：

  氯甲基二乙基甲基硅烷 生成 3-(diethyl-methyl-silanyl)-propionic acid
  参考文献：
  名称：

  与镓基修复材料相关的牙科术后敏感性

  摘要：

  Introduction This study forms part of a 2-year longitudinal clinical trial to compare the performance of a gallium-based restorative material (Galloy) with a high copper, mercury based (Dispersalloy) control material.Method Following Ethical Committee approval, 25 galley restorations and 25 Dispersalloy controls were placed in 14 adult patients, by a single operator. The cavities were of moderate size, indicating the use of amalgam as the restorative material. All restorations were polished within 1 week of placement, photographed and a silicone impression of the tooth and restoration recorded. In addition, a visual analogue scale (VAS), indicating the extent of any post-operative sensitivity, was completed by each patient for each restoration, immediately prior to polishing. A score of 0 indicated no sensitivity, while a score of 10 indicated the greatest possible sensitivity. At B-month recall, the VAS scores, silicone impressions and photographs were repeated.Results The mean sensitivity scores for the galley and Dispersalloy restorations at 1 week were 5.1 (+/-3.4) and 1.0 (+/-1.5), respectively and at 6 months, 1.8 (+/-3.0) and 0.2 (+/-0.1) respectively. The differences between these means at 1 week and at 6 months were significant (P < 0.01).Conclusion Galley restorations were associated with a much greater severity of post-operative sensitivity than Dispersalloy restorations.

  DOI：

  10.1038/sj.bdj.4800755a

文献信息

• Dental post-operative sensitivity associated with a gallium-based restorative material
  作者：S. Dunne、R. Abraham

  DOI：10.1038/sj.bdj.4800755a

  日期：2000.9.23

  Introduction This study forms part of a 2-year longitudinal clinical trial to compare the performance of a gallium-based restorative material (Galloy) with a high copper, mercury based (Dispersalloy) control material.Method Following Ethical Committee approval, 25 galley restorations and 25 Dispersalloy controls were placed in 14 adult patients, by a single operator. The cavities were of moderate size, indicating the use of amalgam as the restorative material. All restorations were polished within 1 week of placement, photographed and a silicone impression of the tooth and restoration recorded. In addition, a visual analogue scale (VAS), indicating the extent of any post-operative sensitivity, was completed by each patient for each restoration, immediately prior to polishing. A score of 0 indicated no sensitivity, while a score of 10 indicated the greatest possible sensitivity. At B-month recall, the VAS scores, silicone impressions and photographs were repeated.Results The mean sensitivity scores for the galley and Dispersalloy restorations at 1 week were 5.1 (+/-3.4) and 1.0 (+/-1.5), respectively and at 6 months, 1.8 (+/-3.0) and 0.2 (+/-0.1) respectively. The differences between these means at 1 week and at 6 months were significant (P < 0.01).Conclusion Galley restorations were associated with a much greater severity of post-operative sensitivity than Dispersalloy restorations.