4-氯-N-另丁基苯甲胺 | 69957-81-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-氯-N-另丁基苯甲胺
• 中文别名: N-对氯苄基另丁胺
• 英文名称: (4-Chlorobenzyl)isobutylamine
• 英文别名: N-[(4-chlorophenyl)methyl]-2-methylpropan-1-amine
• CAS: 69957-81-9
• 化学式: C₁₁H₁₆ClN
• mdl: MFCD00716860
• 分子量: 197.7
• InChiKey: HJCJKLVHXIFTPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2921499090

文献信息

• Oxalic acid derivatives
  申请人：——

  公开号：US20040220411A1

  公开（公告）日：2004-11-04

  Novel compounds of the formula (I) in which R 1 , R 2 , R 3 , R 4 , X and Z are as defined in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic disorders and for the treatment of tumours. 1

  公式（I）中R1、R2、R3、R4、X和Z的定义如专利要求1中所述的新化合物是凝血因子Xa的抑制剂，可用于预防和/或治疗血栓栓塞性疾病以及用于肿瘤治疗。
• IDO inhibitors
  申请人：Bristol-Myers Squibb Company

  公开号：US10689331B2

  公开（公告）日：2020-06-23

  There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

  本发明公开了调节或抑制吲哚胺-2,3-二氧化酶（IDO）酶活性的化合物、含有上述化合物的药物组合物以及利用本发明化合物治疗增殖性疾病（如癌症、病毒感染和/或炎症性疾病）的方法。
• OXALIC ACID DERIVATIVES
  申请人：MERCK PATENT GmbH

  公开号：EP1377543A1

  公开（公告）日：2004-01-07
• IDO INHIBITORS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20190002402A1

  公开（公告）日：2019-01-03

  There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
• [EN] OXALIC ACID DERIVATIVES<br/>[FR] DERIVES D'ACIDE OXALIQUE
  申请人：MERCK PATENT GMBH

  公开号：WO2002083630A1

  公开（公告）日：2002-10-24

  Novel compounds of the formula (I) in which R?1, R2, R3, R4¿, X and Z are as defined in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic disorders and for the treatment of tumours.