3-prop-2-ynyloxy-tetrahydrofuran | 105922-68-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: 3-prop-2-ynyloxy-tetrahydrofuran
• 英文别名: 3-(Propargyloxy)tetrahydrofuran；3-prop-2-ynoxyoxolane
• CAS: 105922-68-7
• 化学式: C₇H₁₀O₂
• 分子量: 126.155
• InChiKey: VQOMGCFFCASDHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Thienopyridones as AMPK activators for the treatment of diabetes and obesity
  申请人：Iyengar R. Rajesh

  公开号：US20050038068A1

  公开（公告）日：2005-02-17

  The present invention relates to compounds that activate AMP-activated protein kinase (AMPK), including the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders such as diabetes, metabolic syndrome, and obesity.

  本发明涉及激活AMP-激活蛋白激酶（AMPK）的化合物，包括制备这些化合物、含有这些化合物的组合物以及利用这些化合物在预防或治疗糖尿病、代谢综合征和肥胖等疾病中的用途。
• [EN] COMPOUNDS, DEVICES, AND USES THEREOF<br/>[FR] COMPOSÉS, DISPOSITIFS ET UTILISATIONS ASSOCIÉES
  申请人：SIGILON THERAPEUTICS INC

  公开号：WO2018067615A1

  公开（公告）日：2018-04-12

  The present invention provides compounds, e.g., compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are implantable elements (e.g., devices and materials) comprising the same, as well as methods of use thereof, e.g., for treating or preventing a disease, disorder, or condition.

  本发明提供化合物，例如，具有式（I）的化合物和药用可接受的盐、溶剂化合物、水合物、互变异构体、立体异构体、同位素标记衍生物及其组合物。还提供包括相同化合物的可植入元件（例如，设备和材料），以及使用方法，例如，用于治疗或预防疾病、紊乱或状况。
• QUINAZOLINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER
  申请人：AstraZeneca AB

  公开号：EP1528925B1

  公开（公告）日：2009-04-22
• COMPOUNDS, DEVICES, AND USES THEREOF
  申请人：SIGILON THERAPEUTICS, INC.

  公开号：US20200039943A1

  公开（公告）日：2020-02-06

  The present invention provides compounds, e.g., compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are implantable elements (e.g., devices and materials) comprising the same, as well as methods of use thereof, e.g., for treating or preventing a disease, disorder, or condition.
• US7119205B2
  申请人：——

  公开号：US7119205B2

  公开（公告）日：2006-10-10