| 1025361-89-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 1025361-89-0
• 化学式: C₃₁H₂₄F₂
• 分子量: 434.528
• InChiKey: NHKDBJKJOSBBQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  、 丁烯酮 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以72%的产率得到5,5-Bis(4-fluorophenyl)-9,9-bis(4-methylphenyl)non-8-en-6-yn-2-one
  参考文献：
  名称：

  LDA-Mediated Selective Addition Reaction of Vinylidenecyclopropanes with Aldehydes, Ketones, and Enones: Facile Synthesis of Vinylcyclopropenes, Allenols, and 1,3-Enynes

  摘要：

  Highly selective addition reaction of vinylidenecyclopropanes 1 was realized by treatment with LDA in THF and quenching with aldehydes, ketones, and enones. A number of vinylcyclopropenes, allenols, and 1,3-enynes were obtained selectively in moderate to good yields depending on the nature of different electrophiles.

  DOI：

  10.1021/ol800463k

文献信息

• LDA-Mediated Cascade Carbolithiation Reactions of Vinylidenecyclopropanes with Enones and N-Sulfonated Imines as well as Nitroalkene and (Phenylmethylidene)malononitrile
  作者：Bei-Li Lu、Jian-Mei Lu、Min Shi

  DOI：10.1002/ejoc.201101403

  日期：2012.1

  LDA-mediated cascade carbolithiation reactions of vinylidenecyclopropanes with enones and N-sulfonated imines as well as nitroalkene and (phenylmethylidene)malononitrile in THF at –78 °C have been realized; the corresponding novel adducts were produced in moderate to good yields with moderate to high diastereoselectivities. The scope and limitations are discussed as well as a plausible reaction mechanism

  LDA介导的亚乙烯基环丙烷与烯酮和N-磺化亚胺以及硝基烯烃和（苯亚甲基）丙二腈在THF中在–78°C的级联碳锂化反应已经实现；相应的新型加合物以中等至良好的收率和中等至高的非对映选择性产生。讨论了范围和限制以及基于本工作和以前的文献报告中进行的控制实验的合理反应机制。
• A Catalytic Method for the Preparation of Polysubstituted Cyclopentanes: [3+2] Cycloaddition of Vinylidenecyclopropanes with Activated Olefins Catalyzed by Triflic Imide
  作者：Wei Li、Min Shi

  DOI：10.1021/jo802294s

  日期：2009.1.16

  [3+2] Cycloadditions of vinylidenecyclopropanes (VDCPs) with electron-deficient olefins, such as methyl vinyl ketone (MVK) and acrylaldehyde, proceed smoothly in the presence of a catalytic amount of triflic imide (Tf2NH) to give the corresponding functionalized cyclopentanes in good to high yields.

  [3 + 2]亚乙烯基环丙烷（VDCPs）与缺电子烯烃如甲基乙烯基酮（MVK）和丙烯醛的环加成反应在催化量的三氟甲基酰亚胺（Tf 2 NH）的存在下平稳进行，得到相应的官能团环戊烷的收率高到高。
• LDA-mediated domino carbolithiation reactions of vinylidenecyclopropanes with but-3-yn-2-one and 1-phenylprop-2-yn-1-one
  作者：Bei-Li Lu、Jian-Mei Lu、Min Shi

  DOI：10.1016/j.tetlet.2009.11.012

  日期：2010.1

  A novel domino carbolithiation reaction of vinylidenecyclopropanes 1 with but-3-yn-2-one and 1-phenylprop-2-yn-1-one by treating with LDA in THF was observed to give the corresponding adducts in moderate to good yields. The scope and limitations as well as the plausible mechanism have been discussed on the basis of control experiments. (C) 2009 Elsevier Ltd. All rights reserved.
• LDA-Mediated Selective Addition Reaction of Vinylidenecyclopropanes with Aldehydes, Ketones, and Enones: Facile Synthesis of Vinylcyclopropenes, Allenols, and 1,3-Enynes
  作者：Jian-Mei Lu、Min Shi

  DOI：10.1021/ol800463k

  日期：2008.5.1

  Highly selective addition reaction of vinylidenecyclopropanes 1 was realized by treatment with LDA in THF and quenching with aldehydes, ketones, and enones. A number of vinylcyclopropenes, allenols, and 1,3-enynes were obtained selectively in moderate to good yields depending on the nature of different electrophiles.