1-chloromethoxy-1H-benzotriazole | 3912-23-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并三唑类
• 英文名称: 1-chloromethoxy-1H-benzotriazole
• 英文别名: 1-(Chloromethoxy)-1H-benzotriazole；1-(chloromethoxy)benzotriazole
• CAS: 3912-23-0
• 化学式: C₇H₆ClN₃O
• 分子量: 183.597
• InChiKey: ZCDPXMIUAUZAQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  39.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  二氯甲烷 、 1-羟基苯并三唑 以100%的产率得到1-chloromethoxy-1H-benzotriazole
  参考文献：
  名称：

  Microwave-Assisted Synthesis Utilizing Supported Reagents:  A Rapid and Efficient Acylation Procedure

  摘要：

  The application of microwave heating to a polymer-assisted solution-phase (PASP) synthesis technique has been utilized to develop a rapid and efficient protocol for the solution-phase synthesis of amides from either amine or carboxylic acid cores.

  DOI：

  10.1021/ol0358915

文献信息

• Studies on the reactions of HOBt, HOOBt, HOSu with dichloroalkane solvents
  作者：Jian-guo Ji、De-yi Zhang、Yun-hua Ye、Qi-yi Xing

  DOI：10.1016/s0040-4039(98)01406-3

  日期：1998.9

  The well known peptide synthesis reagents HOBt, HOOBt and HOSu were found to react with chloroalkane solvents in the presence of triethylamine. Six new compounds were obtained and characterized. (C) 1998 Elsevier Science Ltd. AII rights reserved.