(S)-3-methyl-2-(1-oxo-6-(4-(6-(piperidin-1-yl)nicotinamido)phenyl)isoindolin-2-yl)butanoic acid | 1313577-27-3

• 分子结构分类: 有机化合物
• 英文名称: (S)-3-methyl-2-(1-oxo-6-(4-(6-(piperidin-1-yl)nicotinamido)phenyl)isoindolin-2-yl)butanoic acid
• 英文别名: (2S)-3-methyl-2-[3-oxo-5-[4-[(6-piperidin-1-ylpyridine-3-carbonyl)amino]phenyl]-1H-isoindol-2-yl]butanoic acid
• CAS: 1313577-27-3
• 化学式: C₃₀H₃₂N₄O₄
• 分子量: 512.608
• InChiKey: HYMDYBRTJGXRRD-MHZLTWQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  38
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE
  申请人：Jadhav Ravindra Dnyandev

  公开号：US20120289505A1

  公开（公告）日：2012-11-15

  The present invention relates to heterocyclic compounds in all their stereoisomeric and tautomeric forms; and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutically acceptable polymorphs. The invention also relates to processes for the manufacture of the heterocyclic compounds and to pharmaceutical compositions containing them. The said compounds and their pharmaceutical compositions are useful in the prevention and treatment of diseases or disorders mediated by diacylglycerol acyltransferase (DGAT), particularly DGAT1. The present invention further provides a method of treatment of such diseases or disorders by administering a therapeutically effective amount of said compounds or their pharmaceutical compositions, to a mammal in need thereof.

  本发明涉及杂环化合物及其所有立体异构体和互变异构体；以及它们的药学上可接受的盐，药学上可接受的溶剂化合物和药学上可接受的多晶形态。本发明还涉及制造这些杂环化合物的方法以及含有它们的制药组合物。所述化合物及其制药组合物在预防和治疗由二酰基甘油酰基转移酶（DGAT）介导的疾病或紊乱方面具有用途，尤其是DGAT1。本发明还提供了一种通过向需要治疗的哺乳动物中给予所述化合物或其制药组合物的治疗方法来治疗这些疾病或紊乱的方法。
• US8748426B2
  申请人：——

  公开号：US8748426B2

  公开（公告）日：2014-06-10