(4-Aminophenyl)-(3-bromo-4-fluorophenyl)methanone | 170893-62-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-Aminophenyl)-(3-bromo-4-fluorophenyl)methanone
• 英文别名: (4-aminophenyl)-(3-bromo-4-fluorophenyl)methanone
• CAS: 170893-62-6
• 化学式: C₁₃H₉BrFNO
• 分子量: 294.123
• InChiKey: QQTCYTRYWGFOAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,6-dichlorobenzoyl isocyanate 、 (4-Aminophenyl)-(3-bromo-4-fluorophenyl)methanone 以 苯 为溶剂， 反应 2.0h， 以45%的产率得到
  参考文献：
  名称：

  Studies on the insecticidal activities of some newN-benzoyl-N′-arylureas

  摘要：

  AbstractThis paper reports the synthesis and the insecticidal activities of some N‐benzoyl‐N'‐arylureas 4‐arylsubstituted with alkylated or halogenated aroyl moieties. The compounds, tested against some representative insect species, displayed very high activity against Aedes aegypti, especially the halosubstituted derivatives. None of the newly synthesized compounds showed genotoxic activity in the Bacillus subtilis rec‐assay and in the Salmonella‐microsome test.

  DOI：

  10.1002/ps.2780450306
• 作为产物：
  描述：

  邻溴氟苯 在 盐酸 、 三氯化铝 、 tin(ll) chloride 作用下， 以 乙醇 、 1,2-二氯乙烷 为溶剂， 反应 6.0h， 生成 (4-Aminophenyl)-(3-bromo-4-fluorophenyl)methanone
  参考文献：
  名称：

  Studies on the insecticidal activities of some newN-benzoyl-N′-arylureas

  摘要：

  AbstractThis paper reports the synthesis and the insecticidal activities of some N‐benzoyl‐N'‐arylureas 4‐arylsubstituted with alkylated or halogenated aroyl moieties. The compounds, tested against some representative insect species, displayed very high activity against Aedes aegypti, especially the halosubstituted derivatives. None of the newly synthesized compounds showed genotoxic activity in the Bacillus subtilis rec‐assay and in the Salmonella‐microsome test.

  DOI：

  10.1002/ps.2780450306

文献信息

• Studies on the insecticidal activities of some new<i>N</i>-benzoyl-<i>N′</i>-arylureas
  作者：Maria L. Carmellino、Giuseppe Pagani、Massimo Pregnolato、Marco Terreni、Vincenzo Caprioli、Franca Zani

  DOI：10.1002/ps.2780450306

  日期：1995.11

  AbstractThis paper reports the synthesis and the insecticidal activities of some N‐benzoyl‐N'‐arylureas 4‐arylsubstituted with alkylated or halogenated aroyl moieties. The compounds, tested against some representative insect species, displayed very high activity against Aedes aegypti, especially the halosubstituted derivatives. None of the newly synthesized compounds showed genotoxic activity in the Bacillus subtilis rec‐assay and in the Salmonella‐microsome test.