4-Hydroxy-6-methyl-5-pyrimidine acetic acid | 856153-24-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-Hydroxy-6-methyl-5-pyrimidine acetic acid
• 英文别名: 2-(4-Hydroxy-6-methylpyrimidin-5-yl)acetic acid；2-(4-methyl-6-oxo-1H-pyrimidin-5-yl)acetic acid
• CAS: 856153-24-7
• 化学式: C₇H₈N₂O₃
• 分子量: 168.152
• InChiKey: BSAZTZNTDFVXMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  78.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (6-甲基-2,4-二氧代-1,2,3,4-四氢-5-嘧啶基)乙酸 在 磷化氢 、 五氯化磷 、 氢碘酸 、 三氯氧磷 作用下， 生成 4-Hydroxy-6-methyl-5-pyrimidine acetic acid
  参考文献：
  名称：

  The Synthesis of 4-Methyl-6-oxypyrimidine-5-acetic Acid and 4-Methyluracil-5-methylamine

  摘要：

  DOI：

  10.1021/ja01300a072

文献信息

• 2-amino-5-pyrimidine acetic acid compounds
  申请人：Pharmacia AB

  公开号：US06329383B1

  公开（公告）日：2001-12-11

  The present invention relates to new benzimidazole compounds with the following general structure (I): in which Y—X is >C═X when X is NR8, O, or S and R2 is H, alkyl, substituted alkylaryl or substituted aryl; or Y—X is >C—X when X is H, alkyl, substituted alkyl, aryl, substituted aryl, OR9 or NHR9 and R2 is a bond to Y; Z is O, S or NR12; R1 is H, alkyl, substituted alkyl, aryl or substituted aryl; R3 is H, alkyl, substituted alkyl, aryl or substituted aryl, OR9 or NHR9; R4, R5, R6 and R7 are H, halogen, OR10, NR10, R11, NO2, CF3, CN, COR8, COOR8, CONHR8 and/or N3 in any combination and/or two adjacent R4, R5, R6 or R7 form a carbocyclic or heterocyclic ring; and R8, R9, R10, R11, R12 and R13 are H, alkyl, substituted alkylaryl, aryl and/or substituted aryl in any combination. These compounds are useful as a human Growth Hormone (hGH) mimetic, which trigger GH agonist effects in animals and especially as an orally available human Growth Hormone (hGH).

  本发明涉及具有以下一般结构（I）的新苯并咪唑类化合物：其中当X为NR8，O或S且R2为H，烷基，取代烷基芳基或取代芳基时，Y-X为>C═X；或当X为H，烷基，取代烷基，芳基，取代芳基，OR9或NHR9时，Y-X为>C-X且R2为与Y的键；Z为O，S或NR12；R1为H，烷基，取代烷基，芳基或取代芳基；R3为H，烷基，取代烷基，芳基或取代芳基，OR9或NHR9；R4，R5，R6和R7为H，卤素，OR10，NR10，R11，NO2，CF3，CN，COR8，COOR8，CONHR8和/或N3的任意组合和/或相邻的两个R4，R5，R6或R7形成一个碳环或杂环；R8，R9，R10，R11，R12和R13为H，烷基，取代烷基芳基，芳基和/或取代芳基的任意组合。这些化合物可用作人类生长激素（hGH）类似物，可在动物中引发GH激动剂效应，特别是作为口服可用的人类生长激素（hGH）。
• Pyrimidinyl acrylic acid derivatives, process for their preparation and their use for the control of phytopathogens
  申请人：SANDOZ LTD.

  公开号：EP0634405A1

  公开（公告）日：1995-01-18

  Compounds of formula I wherein R₁is hydrogen, methyl, ethyl or trifluoromethyl, and R₂is hydrogen, methyl, ethyl, C₁₋₄alkylthio, C₁₋₄alkoxy, or di-C₁₋₄alkylamino, and R₃is C₁₋₁₀alkyl, C₁₋₁₀haloalkyl, aryl, heteroaryl, aryl-C₁₋₄alkyl, heteroaryl-C₁₋₄alkyl, aryloxy-C₁₋₄alkyl, aryloxyaryl, arylaryl, heteroaryl, aryl-C₁₋₄alkoxyaryl, aryl-C₁₋₄alkoxy-C₁₋₄alkyl, heteroaryloxyaryl, aryloxy-C₁₋₄alkylaryl or aryl substituted by a group selected from -C(CH₃)=N-O-CH₂-aryl, -C(CH₃)=N-O-CH(CH₃)-aryl, -C(CH₃)=N-C₁₋₄alkoxy, -C(CH₃)=N-C₃₋₄alkenyloxy, -C(CH₃)=N-C₃₋₄alkynyloxy, or -CH₂-O-N=C(CH₃)-aryl, wherein each of the aromatic rings may be optionally substituted; the use of such compounds for the control of phytopathogens, compositions for facilitating such use, and the preparation of the compounds of formula I.

  式 I 的化合物 式中 R₁ 是氢、甲基、乙基或三氟甲基，以及 R₂ 是氢、甲基、乙基、C₁₋₄烷硫基、C₁₋₄烷氧基或二₁₋₄烷基氨基，以及 R₃是 C₁₋₁₀烷基、C₁₋₁₀卤代烷基、芳基、杂芳基、芳基-C₁₋₄烷基、杂芳基-C₁₋₄烷基、芳氧基-C₁₋₄烷基、芳氧基芳基、芳芳基、杂芳基、芳基-C₁₋₄烷氧基芳基、芳基-C₁₋₄烷氧基-C₁₋₄烷基、杂芳氧基芳基、芳氧基-C₁₋₄烷芳基或被选自-C(CH₃)=N-O-CH₂-芳基、-C(CH₃)=N-O-CH(CH₃)-芳基、-C(CH₃)=N-C₁₋₄烷氧基的基团取代的芳基、-C(CH₃)=N-C₃₋₄烯氧基，-C(CH₃)=N-C₃₋₄炔氧基，或-CH₂-O-N=C(CH₃)-芳基，其中每个芳环可任选被取代； 将此类化合物用于控制植物病原体、促进此类用途的组合物，以及式 I 化合物的制备。
• NEW BENZIMIDAZOLE COMPOUNDS FOR USE AS ACTIVE THERAPEUTIC SUBSTANCES, PROCESS FOR THE PREPARATION OF THESE COMPOUDNS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
  申请人：Pharmacia AB

  公开号：EP1155014A1

  公开（公告）日：2001-11-21
• US5453427A
  申请人：——

  公开号：US5453427A

  公开（公告）日：1995-09-26
• US5635508A
  申请人：——

  公开号：US5635508A

  公开（公告）日：1997-06-03