4-氯甲基-6,8-二氟伞形酮-beta-d-吡喃葡糖 | 215868-46-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 中文名称: 4-氯甲基-6,8-二氟伞形酮-beta-d-吡喃葡糖
• 中文别名: 4-(氯甲基)-6,8-二氟-7-(BETA-D-吡喃半乳糖基氧基)-2H-1-苯并吡喃-2-酮
• 英文名称: 4-chloromethyl-6,8-difluoro-7-hydroxycoumarin β-D-galactopyranoside
• 英文别名: 4-Chloromethyl-6,8-difluoroumbelliferyl-b-D-galactopyranoside；4-(chloromethyl)-6,8-difluoro-7-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one
• CAS: 215868-46-5
• 化学式: C₁₆H₁₅ClF₂O₈
• 分子量: 408.74
• InChiKey: ATTAHAWLQLRXSU-DSERSLQPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  126
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• Biological indicator
  申请人：American Sterilizer Company

  公开号：US10011843B2

  公开（公告）日：2018-07-03

  This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for producing an indicator enzyme; a regulatory gene; and a vehicle for inserting the reporter gene and the regulatory gene in the host organism; the host organism bearing a transposable genetic element in its genome for inserting an insertion sequence in the regulatory gene; the insertion sequence comprising a transposase, a pair of terminal inverted repeat sequences, and at least one open reading frame for expressing the transposase. The vehicle may be taken up by the host organism. The insertion sequence may be inserted in the regulatory gene. The host organism may undergo sporulation to form the biological indicator. A process and an apparatus for using the biological indicator are disclosed.

  本发明涉及一种生物指示剂，其成分包括：由形成孢子的细菌组成的宿主生物；产生指示剂酶的报告基因；调控基因；以及将报告基因和调控基因插入宿主生物的载体；宿主生物的基因组中含有转座遗传因子，用于在调控基因中插入插入序列；插入序列包括转座酶、一对末端倒置重复序列和至少一个用于表达转座酶的开放阅读框。载体可被宿主生物吸收。插入序列可插入调控基因中。宿主生物可进行孢子繁殖以形成生物指示剂。本发明公开了一种使用生物指示剂的工艺和装置。
• Method for the detection of viable microorganisms
  申请人：Shaw Erich

  公开号：US20050202523A1

  公开（公告）日：2005-09-15

  Method for the detection and enumeration of viable microorganisms. A liquid that comprises one or more markers incorporated in a liquid sol-gel precursor, is provided. A transparent slide is coated with a thin uniform layer of the liquid sol-gel precursor composition. The microorganisms are separated from liquid sample to be analyzed by passing the sample through a filter, and then bringing the filter into close contact with the sol-gel coated slide. The filter is co-incubated with the sol-gel coated slide for a period of time and at a temperature suitable to promote uptake of the markers by the microorganisms. The gel-coated slide irradiated with an external energy source, so as to generate detectable signals emitted from the markers uptaken by the microorganisms. Image of the detectable signals emitted from the microorganisms are acquired, and analyzed using a computer system, in order to provide the identification and enumeration of the microorganisms.

  可存活微生物的检测和计数方法。提供一种液体，其中包含一种或多种掺入液体溶胶-凝胶前体的标记物。在透明载玻片上涂上一层均匀的液态溶胶-凝胶前驱体薄层。将样品通过过滤器，然后使过滤器与涂有溶胶凝胶的载玻片紧密接触，从而将微生物从待分析的液体样品中分离出来。将过滤器与涂有溶胶凝胶的载玻片在适当的温度下共同培养一段时间，以促进微生物对标记物的吸收。用外部能源照射涂有凝胶的载玻片，以产生微生物吸收标记物后发出的可检测信号。获取微生物发出的可检测信号的图像，并使用计算机系统进行分析，以便对微生物进行识别和计数。
• A METHOD FOR THE DETECTION OF VIABLE MICROORGANISMS
  申请人：Biogem Ltd.

  公开号：EP1337658A2

  公开（公告）日：2003-08-27
• GENETICALLY ENGINEERED BIOLOGICAL INDICATOR
  申请人：American Sterilizer Company

  公开号：EP2084293B1

  公开（公告）日：2014-08-13
• STERILIZATION INDICATOR INCLUDING A SIMPLIFIED GENETICALLY ENGINEERED BIOLOGICAL INDICATOR
  申请人：American Sterilizer Company

  公开号：EP2970992B1

  公开（公告）日：2018-07-25