4’-chloro-5-chloro-2-hydroxybenzenesulfonanilide | 91588-17-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4’-chloro-5-chloro-2-hydroxybenzenesulfonanilide
• 英文别名: 5-chloro-2-hydroxy-benzenesulfonic acid-(4-chloro-anilide)；5-Chlor-2-hydroxy-benzolsulfonsaeure-(4-chlor-anilid)
• CAS: 91588-17-9
• 化学式: C₁₂H₉Cl₂NO₃S
• 分子量: 318.18
• InChiKey: UUFUVRCJUGGZJM-UHFFFAOYSA-N

文献信息

• Sulfonamide Bioisosteres of Niclosamide Enhance Antibacterial Activity of Colistin and Bacitracin
  作者：Liam Berry、Danyel Ramirez、Ronald Domalaon、Frank Schweizer

  DOI：10.1002/cmdc.202400175

  日期：2024.8

  In this study, eight sulfonamide analogs of niclosamide were prepared. Compound 7 synergizes with colistin (COL) against Gram-negative bacteria. Moreover, combining bacitracin (BAC) with compound 7 further improves the antibacterial activity of COL against COL-resistant Gram-negative bacteria. Interestingly, compound 7 was also shown to synergize with BAC against Gram-positive bacteria such as vancomycin-resistant

  在本研究中，制备了氯硝柳胺的八种磺酰胺类似物。化合物7与粘菌素 (COL) 协同对抗革兰氏阴性菌。此外，杆菌肽（BAC）与化合物7联合进一步提高了COL对COL耐药革兰氏阴性菌的抗菌活性。有趣的是，化合物7还被证明可以与 BAC 协同对抗革兰氏阳性菌，例如耐万古霉素的屎肠球菌临床分离株。