3-Benzothiazol-2-yl-5,7,7,8-tetramethyl-5,6,7,8-tetrahydro-1-oxa-8-aza-anthracen-2-one | 41381-96-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 3-Benzothiazol-2-yl-5,7,7,8-tetramethyl-5,6,7,8-tetrahydro-1-oxa-8-aza-anthracen-2-one
• 英文别名: 3-(1,3-Benzothiazol-2-yl)-6,8,8,9-tetramethyl-6,7-dihydropyrano[3,2-g]quinolin-2-one
• CAS: 41381-96-8
• 化学式: C₂₃H₂₂N₂O₂S
• 分子量: 390.506
• InChiKey: LYMPKDRUCBGUCP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  28
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  70.7
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• CYCLOOCTATETRAENE CONTAINING DYES AND COMPOSITIONS
  申请人：Illumina Cambridge Limited

  公开号：US20210155983A1

  公开（公告）日：2021-05-27

  Embodiments of the present disclosure relate to cyclooctatetraene containing dyes and their uses as fluorescent labels. Also provided are composition containing cyclooctatetraene. The dyes and compositions may be used in various biological applications, such as nucleic acid sequencing.

  本公开的实施例涉及含有环辛四烯染料及其用作荧光标记的用途。还提供了含有环辛四烯的组合物。这些染料和组合物可用于各种生物应用，例如核酸测序。
• Coumarin compounds and their uses as fluorescent labels
  申请人：Illumina Cambridge Limited

  公开号：US10907196B2

  公开（公告）日：2021-02-02

  The present application relates to new coumarin compounds and their uses as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.

  本申请涉及新型香豆素化合物及其作为荧光标记的用途。这些化合物可用作核酸测序应用中核苷酸的荧光标签。
• COUMARIN COMPOUNDS AND THEIR USES AS FLUORESCENT LABELS
  申请人：Illumina Cambridge Limited

  公开号：US20180201981A1

  公开（公告）日：2018-07-19

  The present application relates to new coumarin compounds and their uses as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.
• METHODS AND COMPOSITIONS FOR NUCLEIC ACID SEQUENCING
  申请人：Illumina Cambridge Limited

  公开号：US20220195518A1

  公开（公告）日：2022-06-23

  Embodiments of the present disclosure relate to methods, kits and compositions for two-channel nuclei acid sequencing using blue and violet light excitation (e.g., lasers at 450-460 nm and 400-405 nm respectively). In particular, the nucleotides may be directly labeled with a blue dye, a violet dye, or both a blue dye and a violet dye. Alternatively, one or more nucleotides for incorporation may be unlabeled and affinity reagents containing a blue dye, a violet dye, or both a blue dye and a violet dye may be used to bind specifically to each type of nucleotides incorporated.
• [EN] METHODS AND COMPOSITIONS FOR NUCLEIC ACID SEQUENCING<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR LE SÉQUENÇAGE D'ACIDES NUCLÉIQUES
  申请人：[en]ILLUMINA CAMBRIDGE LIMITED

  公开号：WO2022136402A1

  公开（公告）日：2022-06-30

  Embodiments of the present disclosure relate to methods, kits and compositions for two- channel nuclei acid sequencing using blue and violet light excitation (e.g., lasers at 450-460 nm and 400-405 nm respectively). In particular, the nucleotides may be directly labeled with a blue dye, a violet dye, or both a blue dye and a violet dye. Alternatively, one or more nucleotides for incorporation may be unlabeled and affinity reagents containing a blue dye, a violet dye, or both a blue dye and a violet dye may be used to bind specifically to each type of nucleotides incorporated.