N,N-diallyl-N'-benzoylhydrazine | 33233-42-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-diallyl-N'-benzoylhydrazine
• 英文别名: N',N'-bis(prop-2-enyl)benzohydrazide
• CAS: 33233-42-0
• 化学式: C₁₃H₁₆N₂O
• 分子量: 216.283
• InChiKey: XQJMJFGNZNJCRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N-diallyl-N'-benzoylhydrazine 在 亚硝酸特丁酯 、 氧气 作用下， 以 氯仿 为溶剂， 以53%的产率得到N-allyl-N′-benzoylnitrous hydrazide
  参考文献：
  名称：

  C–N Bond Activation of N,N′-Dialkylacylhydrazines Mediated by β-Fragmentation of Nitrogen-Centered Radical

  摘要：

  In the presence of tert-butylnitrite and dioxygen, the C-N bond activation of N,N'-dialkylacylhydrazines was realized, providing a series of N-nitrosoacylhydrazines in high yields. Different from transition-metal and other radical catalysis, this reaction is mediated by a nitrogen-centered radical of the corresponding N,N'-dialkylacylhydrazine and further beta-fragmentation, which was supported by the mechanistic study.

  DOI：

  10.1021/acs.joc.9b01851
• 作为产物：
  描述：

  苯甲酰肼 、 alkaline earth salt of/the/ methylsulfuric acid 生成 N,N-diallyl-N'-benzoylhydrazine
  参考文献：
  名称：

  Copolymers Based on Diallylhydrazines

  摘要：

  The possibility of preparing polymers based on N,N-diallylhydrazine derivatives by allylation of carboxylic acid hydrazides was considered.

  DOI：

  10.1023/b:rjac.0000044167.00715.3b

文献信息

• Tin-Mediated One-Pot Synthesis of α,α-Disubstituted Homoallylic Hydrazides from Ketones, Acylhydrazines and Allyl Bromide
  作者：Danfeng Huang、Yulai Hu、Ailing Lu、Ke-Hu Wang、Yingpeng Su、Junyan Ma、Yanli Xu

  DOI：10.1055/s-0035-1560803

  日期：——

  An efficient multicomponent one-pot reaction was developed for the synthesis of ,-disubstituted homoallylic hydrazides by treating ketones, acylhydrazines and allyl bromide with tin powder in tetrahydrofuran under reflux. The reaction proceeds smoothly without any catalyst under mild conditions to give the corresponding products in high yields.
• Yeung; Knaus, European Journal of Medicinal Chemistry, 1986, vol. 21, # 3, p. 181 - 185
  作者：Yeung、Knaus

  DOI：——

  日期：——
• C–N Bond Activation of <i>N</i>,<i>N′</i>-Dialkylacylhydrazines Mediated by β-Fragmentation of Nitrogen-Centered Radical
  作者：Yuxian Zhang、Shuwei Zhang、Zheng Sun、Kaixuan He、Qian Chen、Yu Yuan、Xiaodong Jia

  DOI：10.1021/acs.joc.9b01851

  日期：2019.11.1

  In the presence of tert-butylnitrite and dioxygen, the C-N bond activation of N,N'-dialkylacylhydrazines was realized, providing a series of N-nitrosoacylhydrazines in high yields. Different from transition-metal and other radical catalysis, this reaction is mediated by a nitrogen-centered radical of the corresponding N,N'-dialkylacylhydrazine and further beta-fragmentation, which was supported by the mechanistic study.
• YEUNG, J. M.;KNAUS, E. E., EUR. J. MED. CHEM., 1986, 21, N 3, 181-185
  作者：YEUNG, J. M.、KNAUS, E. E.

  DOI：——

  日期：——
• QUATERNARY SALTS OF PARA-DIALKYLAMINO BENZAMIDE DERIVATIVES
  申请人：ISP Van Dyk Inc.

  公开号：EP0738138A1

  公开（公告）日：1996-10-23