| 1433131-93-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• CAS: 1433131-93-1
• 化学式: C₂HF₃O₂*C₁₁H₁₁Br₂N₅O
• 分子量: 503.073
• InChiKey: FETNQMDWUPVIOC-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  三氟乙酸 、 Oroidin 在 bis(tetrabutylammonium) dimethyl p-xylylenediphosphonate 作用下， 以 二甲基亚砜 、 甲醇 、 水 为溶剂， 反应 6.0h， 以5%的产率得到N-[3-[2-amino-5-[[2-(4,5-dibromo-1H-pyrrol-2-yl)-4,5-dihydro-1,3-oxazol-5-yl]methyl]-1H-imidazol-4-yl]-3-(2-amino-1H-imidazol-5-yl)propyl]-4,5-dibromo-1H-pyrrole-2-carboxamide
  参考文献：
  名称：

  Unprecedented Biomimetic Homodimerization of Oroidin and Clathrodin Marine Metabolites in the Presence of HMPA or Phosphonate Salt Tweezers

  摘要：

  The first biomimetic homodimerization of oroidin and clathrodin was effected in the presence HMPA and diphosphonate salts, strong guanidinium and amide chelating agents. The intermolecular associations probably interfere with the entropically and kinetically favored intramolecular cyclizations. Use of oroidin.1/2HCl salt or clathrodin.1/2HCl was indicative in the presence of the ambident nucleophilic and electrophilic tautomers of the 2-aminoimidazolic oroidin and clathrodin precursors. Surprisingly, the homodimerization of oroidin led to the nagelamide D skeleton, while the homodimerization of clathrodin gave the benzene para-symmetrical structure 19. The common process was rationalized from tautomeric precursors I and III.

  DOI：

  10.1021/np400048r