benzyl 3-(butylamino)but-2-enoate | 949573-21-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl 3-(butylamino)but-2-enoate
• 英文别名: Benzyl 3-butylaminobut-2-enoate
• CAS: 949573-21-1
• 化学式: C₁₅H₂₁NO₂
• 分子量: 247.337
• InChiKey: PKVMAYAKTACEAO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  乙酰丙酮苄酯 、 正丁胺 在 SbCl₃/SiO₂ 作用下， 反应 0.37h， 以92%的产率得到benzyl 3-(butylamino)but-2-enoate
  参考文献：
  名称：

  Silica-supported antimony(III) chloride as an efficient heterogeneous catalyst for the synthesis of aminopropenones and 3-aminopropenoates under solvent-free conditions

  摘要：

  A convenient and efficient procedure has been developed for the synthesis of 3-aminoprop-2-en-1-ones and 3-aminoprop-2-enoates catalyzed by silica-supported antimony(III) chloride at room temperature under solvent-free conditions. The reaction takes a short time and ensures good to excellent yields of the products. Both aromatic and aliphatic amines and various 1,3-dicarbonyl compounds, including beta-ketoesters and beta-diketones, can be involved.

  DOI：

  10.1134/s1070428009010023

文献信息

• Simple and efficient synthesis of 3-aminopropenones and 3-aminopropenoates catalyzed by copper(II) nitrate trihydrate under solvent-free conditions
  作者：Geng-Chen Li

  DOI：10.1007/s00706-007-0832-x

  日期：2008.7

  A simple, efficient and environmentally begin method has been developed for the synthesis of 3-aminopropenones and 3-aminopropenoates through the reaction of 1,3-dicarbonyl compounds with amines in the presence of Cu(NO(3))(2) center dot 3H(2)O under solvent-free conditions.