methyl 3-hydroxy-3-(3-methoxy-4,5-methylenedioxyphenyl)propionate | 109856-94-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: methyl 3-hydroxy-3-(3-methoxy-4,5-methylenedioxyphenyl)propionate
• 英文别名: methyl 3-hydroxy-3-(7-methoxy-1,3-benzodioxol-5-yl)propanoate
• CAS: 109856-94-2
• 化学式: C₁₂H₁₄O₆
• 分子量: 254.24
• InChiKey: HAXDHLKDFMSBMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  74.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  methyl 3-methoxy-4,5-methylenedioxybenzoylacetate 在 钯 氢气 、 甲醇 作用下， 以 甲醇 为溶剂， 以there was obtained 202 mg of methyl 3-hydroxy-3-(3-methoxy-4,5-methylenedioxyphenyl)propionate (11) as an oil with a quantitative yield的产率得到methyl 3-hydroxy-3-(3-methoxy-4,5-methylenedioxyphenyl)propionate
  参考文献：
  名称：

  Anisole derivatives

  摘要：

  提供了一种新的苯甲醚衍生物，其化学式如下（I）：##STR1## 其中A至D的定义如下：（1）A、B和C分别是氢原子，D代表--OH、卤素原子、--CO.sub.2R.sup.1，其中R.sup.1代表低烷基、--SO.sub.2R.sup.2，其中R.sup.2代表低烷基，或##STR2## 或（2）A和C分别是氢原子，B是--OH，D代表--CO.sub.2R.sup.3，其中R.sup.3代表低烷基；或（3）A是氢原子，B和C形成一个氧代基.dbd.O，D代表--CO.sub.2R.sup.4，其中R.sup.4代表低烷基；或（4）B和C分别是氢原子，D是卤素原子，A代表--CHO。

  公开号：

  US04746747A1

文献信息

• Method for synthesizing chiral beta-hydroxy acid ester compound
  申请人：Wenzhou University

  公开号：US10906860B2

  公开（公告）日：2021-02-02

  A method for synthesizing a chiral β-hydroxy acid ester compound is disclosed. The method includes the steps of: using an aldehyde compound and a monoalkyl malonate as raw materials, using a metal and a chiral ligand as a catalyst to make the raw materials be directly and fully reacted in an organic solvent and form a reaction solution, and separating and purifying the reaction solution to obtain the highly stereoselective β-hydroxy acid ester compound. The beneficial effects are mainly embodied in: 1. simple operation; 2. rapidly constructing a highly stereoselective β-hydroxy acid ester skeleton structure molecule; 3. high reaction yield and good stereoselectivity. Therefore, the invention has high basic research significance, industrial production value and social economic benefit.

  本发明公开了一种合成手性β-羟基酸酯化合物的方法。该方法包括以下步骤：以醛类化合物和丙二酸单烷基酯为原料，以金属和手性配体为催化剂，使原料在有机溶剂中直接充分反应，形成反应溶液，分离纯化反应溶液，得到高立体选择性的β-羟基酸酯化合物。其优点主要体现在1.操作简单；2.快速构建高立体选择性的β-羟基酸酯骨架结构分子；3.反应产率高，立体选择性好。因此，本发明具有较高的基础研究意义、工业生产价值和社会经济效益。
• METHOD FOR SYNTHESIZING CHIRAL BETA-HYDROXY ACID ESTER COMPOUND
  申请人：Wenzhou University

  公开号：US20200190013A1

  公开（公告）日：2020-06-18

  A method for synthesizing a chiral β-hydroxy acid ester compound is disclosed. The method includes the steps of: using an aldehyde compound and a monoalkyl malonate as raw materials, using a metal and a chiral ligand as a catalyst to make the raw materials be directly and fully reacted in an organic solvent and form a reaction solution, and separating and purifying the reaction solution to obtain the highly stereoselective β-hydroxy acid ester compound. The beneficial effects are mainly embodied in: 1. simple operation; 2. rapidly constructing a highly stereoselective β-hydroxy acid ester skeleton structure molecule; 3. high reaction yield and good stereoselectivity. Therefore, the invention has high basic research significance, industrial production value and social economic benefit.
• US4746747A
  申请人：——

  公开号：US4746747A

  公开（公告）日：1988-05-24