2-[6-(4-hydroxy-3,5-dimethyl-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid methyl ester | 870100-06-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-[6-(4-hydroxy-3,5-dimethyl-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid methyl ester
• 英文别名: methyl 2-[3-(4-hydroxy-3,5-dimethylphenyl)-6-oxo-1H-pyridazin-5-yl]-1H-pyrrolo[2,3-c]pyridine-5-carboxylate
• CAS: 870100-06-4
• 化学式: C₂₁H₁₈N₄O₄
• 分子量: 390.398
• InChiKey: OAJNKGCBKABRSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  117
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] PYRIDAZINONE DERIVATIVES, METHODS FOR PRODUCING THEM AND THEIR USE AS PHARMACEUTICALS<br/>[FR] DERIVES DE PYRIDAZINONE, PROCEDES DE PRODUCTION DE CES DERIVES ET LEUR UTILISATION COMME PHARMACEUTIQUES
  申请人：AVENTIS PHARMA GMBH

  公开号：WO2005111018A1

  公开（公告）日：2005-11-24

  The present invention relates to compounds according to the general formula (I), with the definitions of the substituents X, R1 and R2 given below in the text, as well as their physiologically acceptable salts, methods for producing these compounds and their use as pharmaceuticals. Formula (I) These compounds are kinase inhibitors, in particular inhibitors of the kinase GSK­15 30 (glycogen synthase kinase-3ß).

  本发明涉及通式（I）所示的化合物，其中下文给出了取代基X、R1和R2的定义，以及它们的生理上可接受的盐，生产这些化合物的方法以及它们作为药物的用途。通式（I）这些化合物是激酶抑制剂，特别是激酶GSK-15 30（糖原合成酶激酶-3ß）的抑制剂。
• PYRIDAZINONE DERIVATIVES, METHODS FOR THEIR PRODUCTION AND THEIR USE AS PHARMACEUTICALS
  申请人：Hoelder Swen

  公开号：US20070088041A1

  公开（公告）日：2007-04-19

  The present invention relates to compounds according to the general formula (I), with the definitions of the substituents X, R 1 and R 2 given below in the text, as well as their physiologically acceptable salts, methods for producing these compounds and their use as pharmaceuticals. These compounds are kinase inhibitors, in particular inhibitors of the kinase GSK-3β(glycogen synthase kinase-3β).

  本发明涉及符合通式（I）的化合物，其中X，R1和R2的定义如下文所述，以及它们的生理学上可接受的盐，制备这些化合物的方法以及它们作为药物的用途。这些化合物是激酶抑制剂，特别是激酶GSK-3β（糖原合成酶激酶-3β）的抑制剂。
• PYRIDAZINONE DERIVATIVES, METHODS FOR PRODUCING THEM AND THEIR USE AS PHARMACEUTICALS
  申请人：Sanofi-Aventis Deutschland GmbH

  公开号：EP1753743A1

  公开（公告）日：2007-02-21
• US7709466B2
  申请人：——

  公开号：US7709466B2

  公开（公告）日：2010-05-04