4-(2-bromoethoxy)phenylacetamide | 125174-27-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(2-bromoethoxy)phenylacetamide
• 英文别名: 2-[4-(2-Bromoethoxy)phenyl]acetamide
• CAS: 125174-27-8
• 化学式: C₁₀H₁₂BrNO₂
• 分子量: 258.115
• InChiKey: KAGNNXKHADGWJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(2-bromoethoxy)phenylacetamide 在 氢气 、 potassium carbonate 、 sodium iodide 作用下， 以 乙醇 、 二氯甲烷 、 乙腈 为溶剂， 反应 72.0h， 生成 2-[4-(2-{[2-(4-Methanesulfonylamino-phenyl)-ethyl]-methyl-amino}-ethoxy)-phenyl]-acetamide; compound with methanesulfonic acid
  参考文献：
  名称：

  Selective class III antiarrhythmic agents. 1. Bis(arylalkyl)amines

  摘要：

  A series of bis(arylalkyl)amines is described and their effects on prolonging effective refractory period in isolated cardiac tissue listed. Most compounds prolonged the cardiac action potential without significantly altering the maximum rate of depolarization and may be defined as selective class III antiarrhythmic agents. It was found that a particularly advantageous structural feature was to have a methanesulfonamido moiety on both of the aryl rings. Thus, compound 16 [1-(4-methanesulfonamidophenoxy)2-[N-(4-methanesulfonamidophene thyl)-N- methylamine]ethane] was selected for further investigations. The compound is highly potent and selective class III agent which acts by blockade of cardiac potassium channels.

  DOI：

  10.1021/jm00166a011

文献信息

• Chemical compounds
  申请人：Zeneca Limited

  公开号：US05393779A1

  公开（公告）日：1995-02-28

  Compounds of the formula (I): ##STR1## and bioprecursors and pharmaceutically acceptable salts thereof are described as .beta..sub.3 -adrenoceptor agonists having anti-obesity, hypoglycaemic and related therapeutic utilities. Processes for their preparation are described as are compositions containing them.

  本文描述了化学式（I）的化合物及其生物前体和药学上可接受的盐，作为具有抗肥胖、降血糖和相关治疗用途的β3-肾上腺素受体激动剂。本文还描述了其制备过程以及含有它们的组合物。
• Novel phenylacetamide derivatives and processes for the preparation thereof
  申请人：KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

  公开号：EP0525360B1

  公开（公告）日：1998-03-25
• CROSS, PETER E.;ARROWSMITH, JOHN E.;THOMAS, GEOFFREY N.;GWILT, MICHAEL;BU+, J. MED. CHEM., 33,(1990) N, C. 1151-1155
  作者：CROSS, PETER E.、ARROWSMITH, JOHN E.、THOMAS, GEOFFREY N.、GWILT, MICHAEL、BU+

  DOI：——

  日期：——
• 2-Hydroxy-2-phenylethylamine derivatives as beta-3-adrenoceptor agonists
  申请人：ZENECA LIMITED

  公开号：EP0516349B1

  公开（公告）日：1995-09-20
• US5242944A
  申请人：——

  公开号：US5242944A

  公开（公告）日：1993-09-07