4-<4-Amino-phenyl>-valeriansaeure | 74317-87-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-<4-Amino-phenyl>-valeriansaeure
• 英文别名: 4-(4-amino-phenyl)-valeric acid；4-(4-Amino-phenyl)-valeriansaeure；4-(4-Aminophenyl)pentanoic acid
• CAS: 74317-87-6
• 化学式: C₁₁H₁₅NO₂
• 分子量: 193.246
• InChiKey: ZQXURPDUPQBSAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 ammonium hydroxide 作用下， 生成 4-<4-Amino-phenyl>-valeriansaeure
  参考文献：
  名称：

  Colonge; Fichet, Bulletin de la Societe Chimique de France, 1955, p. 412,414

  摘要：

  DOI：

文献信息

• [EN] INHIBITORS OF HISTONE DEACETYLASE<br/>[FR] INHIBITEURS DE L'HISTONE DEACETYLASE
  申请人：METHYLGENE INC

  公开号：WO2001038322A1

  公开（公告）日：2001-05-31

  The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

  本发明涉及抑制组蛋白去乙酰化酶。本发明提供了抑制组蛋白去乙酰化酶酶活性的化合物和方法。本发明还提供了治疗细胞增殖性疾病和病状的组合物和方法。
• INHIBITORS OF HISTONE DEACETYLASE AND PRODRUGS THEREOF
  申请人：Deziel Robert

  公开号：US20080146623A1

  公开（公告）日：2008-06-19

  The invention relates to the inhibition of histone deacetylase. The invention provides compounds, prodrugs thereof, and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

  本发明涉及抑制组蛋白去乙酰化酶的技术。本发明提供了抑制组蛋白去乙酰化酶酶活性的化合物、前药及其方法。本发明还提供了治疗细胞增殖性疾病和病症的组合物和方法。
• Substituted 4,10-dihydro-10-oxothieno benzoxepins, a method of preparing the same and intermediate thereof and their use as medicaments
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

  公开号：EP0118867A2

  公开（公告）日：1984-09-19

  There are described substituted 4,10-dihydro-10-oxothienobenzoxepins of the formula wherein R is hydrogen, loweralkyl, or -CH2CH(OH)CH2OH; R1 is hydrogen or loweralkyl; and R2 is hydrogen or loweralkyl, which are useful as anti-inflammatory and analgetic agents, intermediate compounds therefor, and a method of preparing the same.

  描述了式中 R 为氢、低级烷基或-CH2CH(OH)CH2OH；R1 为氢或低级烷基；R2 为氢或低级烷基的取代的 4,10-二氢-10-氧代噻吩并氧杂环庚烷，它们可用作消炎和镇痛剂、其中间化合物以及制备方法。
• Polyphenylene ether resin composition
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：EP0131445A2

  公开（公告）日：1985-01-16

  @ A polyphenylene ether resin composition comprising (A) a polyphenylene ether resin, and (B) an aromatic polyamide having a melting point of up to 330°C composed mainly of at least one kind of recurring structural units containing an aromatic nucleus represented for formula (I) wherein R' represents an alkylenephenylene or dialkylenephenylene group, or formula (II) wherein R2 represents a phenylene, dialkylenephenylene or biphenylene group or a group of the following formula in which X represents an alkylene group having 1 to 5 carbon atoms, an oxygen atom, a sulfur atom, a carbonyl group or a sulfonyl group, and R3 represents an alkylene group having 3 to 10 carbon atoms, a phenylene group or a naphthylene group.

  一种聚苯醚树脂组合物，包括(A)聚苯醚树脂和(B)芳香族聚酰胺，其熔点高达 330°C，主要由至少一种含有芳香族核的重复结构单元组成，如式(I)所示，其中 R'代表烷基亚苯基或二烷基亚苯基基团，或式(II)所示，其中 R2 代表亚苯基、二烷基亚苯基或联苯基团或下式基团，其中 X 代表具有 1 至 5 个碳原子的亚烷基、氧原子、硫原子、羰基或磺酰基，R3 代表具有 3 至 10 个碳原子的亚烷基、亚苯基或亚萘基。
• Inhibitors of histone deacetylase
  申请人：Methylgene, Inc.

  公开号：EP1748046A2

  公开（公告）日：2007-01-31

  The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

  本发明涉及组蛋白去乙酰化酶的抑制。本发明提供了抑制组蛋白去乙酰化酶酶活性的化合物和方法。本发明还提供了治疗细胞增殖性疾病和病症的组合物和方法。