5-(5-chloropyrimidin-4-yl)-4-methyl-1,2-dithiole-3-thione | 64224-43-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-(5-chloropyrimidin-4-yl)-4-methyl-1,2-dithiole-3-thione
• 英文别名: 5-(5-Chloropyrimidin-4-yl)-4-methyldithiole-3-thione
• CAS: 64224-43-7
• 化学式: C₈H₅ClN₂S₃
• 分子量: 260.792
• InChiKey: NOGXRGAZLBHRJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  109
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Dithiolthione compounds for the treatment of neurological disorders and for memory enhancement
  申请人：Patrick Prendergast

  公开号：US20040053989A1

  公开（公告）日：2004-03-18

  The invention provides methods to treat neurological disorders such as Alzheimer's disease, or to slow the progression of such diseases, or to treat and/or prevent other disorders as disclosed in the specification, by administering to patients, or delivering to the tissues of such patients, oltipraz or related compounds as disclosed in the specification.

  该发明提供了治疗神经系统疾病，如阿尔茨海默病的方法，或减缓这些疾病的进展，或治疗和/或预防其他疾病的方法，通过向患者或向这些患者的组织输送在规范中披露的oltipraz或相关化合物。
• US4144339A
  申请人：——

  公开号：US4144339A

  公开（公告）日：1979-03-13
• US4110450A
  申请人：——

  公开号：US4110450A

  公开（公告）日：1978-08-29
• US4138487A
  申请人：——

  公开号：US4138487A

  公开（公告）日：1979-02-06
• [EN] DITHIOLTHIONE COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS AND FOR MEMORY ENHANCEMENT<br/>[FR] COMPOSES DITHIOLTHIONE POUR LE TRAITEMENT DE TROUBLES NEUROLOGIQUES ET POUR RENFORCER LA MEMOIRE
  申请人：PRENDERGAST PATRICK T

  公开号：WO2001009118A2

  公开（公告）日：2001-02-08

  The invention provides methods to treat neurological disorders such as Alzheimer's disease, or to slow the progression of such diseases, or to treat and/or prevent other disorders as disclosed in the specification, by administering to patients, or delivering to the tissues of such patients, oltipraz or related compounds as disclosed in the specification.