(S)-2-(3-methylmorpholino)-N-((2-(trifluoromethyl)pyridin-3-yl)methyl)pyrido[2,3-d]pyrimidin-4-amine | 2239272-16-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: (S)-2-(3-methylmorpholino)-N-((2-(trifluoromethyl)pyridin-3-yl)methyl)pyrido[2,3-d]pyrimidin-4-amine
• 英文别名: 2-[(3S)-3-methylmorpholin-4-yl]-N-[[2-(trifluoromethyl)pyridin-3-yl]methyl]pyrido[2,3-d]pyrimidin-4-amine
• CAS: 2239272-16-1
• 化学式: C₁₉H₁₉F₃N₆O
• 分子量: 404.395
• InChiKey: IZFVCNUAPFSNCO-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  76.1
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  (S)-2-(3-methylmorpholino)-N-((2-(trifluoromethyl)pyridin-3-yl)methyl)pyrido[2,3-d]pyrimidin-4-amine 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 以72.8 %的产率得到2-[(S)-3-methylmorpholin-4-yl]-N-[2-(trifluoromethyl)pyridin-3-yl]methylpyrido[2,3-d]pyrimidin-4-amine hemihydrochloride
  参考文献：
  名称：

  Transformation of the Manufacturing Process from Discovery to Kilogram Scale for AWZ1066S: A Highly Specific Anti-Wolbachia Drug Candidate for a Short-Course Treatment of Filariasis

  摘要：

  DOI：

  10.1021/acs.oprd.2c00167
• 作为产物：
  描述：

  (2-三氟甲基-吡啶-3-基)-甲醇 在 potassium phosphate 、 potassium carbonate 、 三乙胺 、 甲胺 作用下， 以 四氢呋喃 、 N-甲基吡咯烷酮 、 二氯甲烷 、 水 、 二甲基亚砜 为溶剂， 反应 17.5h， 生成 (S)-2-(3-methylmorpholino)-N-((2-(trifluoromethyl)pyridin-3-yl)methyl)pyrido[2,3-d]pyrimidin-4-amine
  参考文献：
  名称：

  Transformation of the Manufacturing Process from Discovery to Kilogram Scale for AWZ1066S: A Highly Specific Anti-Wolbachia Drug Candidate for a Short-Course Treatment of Filariasis

  摘要：

  DOI：

  10.1021/acs.oprd.2c00167

文献信息

• Anti-Wolbachia pyrido[2,3-d]pyrimidine compounds
  申请人：Liverpool School of Tropical Medicine

  公开号：US11518760B2

  公开（公告）日：2022-12-06

  The present invention relates to compounds of Formulae (I) and (II) as defined herein, and salts and solvates thereof. The present invention also relates to pharmaceutical compositions comprising compounds of Formulae (I) and (II), and to the use of compounds of Formulae (I) and (II) in the treatment or prevention of filarial worm infection, as well as other diseases or conditions in which filarial worm infection is implicated.

  本发明涉及本文定义的式(I)和(II)化合物及其盐类和溶剂。 本发明还涉及包含式（I）和（II）化合物的药物组合物，以及式（I）和（II）化合物在治疗或预防丝虫感染以及丝虫感染引起的其他疾病或病症中的用途。
• COMPOUNDS
  申请人：Liverpool School of Tropical Medicine

  公开号：US20190345157A1

  公开（公告）日：2019-11-14

  The present invention relates to compounds of Formulae (I) and (II) as defined herein, and salts and solvates thereof. The present invention also relates to pharmaceutical compositions comprising compounds of Formulae (I) and (II), and to the use of compounds of Formulae (I) and (II) in the treatment or prevention of filarial worm infection, as well as other diseases or conditions in which filarial worm infection is implicated.
• [EN] COMPOUNDS<br/>[FR] COMPOSÉS
  申请人：LIVERPOOL SCHOOL TROPICAL MEDICINE

  公开号：WO2018134685A2

  公开（公告）日：2018-07-26

  The present invention relates to compounds of Formulae (I) and (II) as defined herein, and salts and solvates thereof. The present invention also relates to pharmaceutical compositions comprising compounds of Formulae (I) and (II), and to the use of compounds of Formulae (I) and (II) in the treatment or prevention of filarial worm infection, as well as other diseases or conditions in which filarial worm infection is implicated.
• [EN] AZAQUINAZOLINE DERIVATIVES FOR USE IN TREATING OR PREVENTING DIROFILARIA INFECTION IN A MAMMAL<br/>[FR] DÉRIVÉS D'AZAQUINAZOLINE POUR LEUR UTILISATION DANS LE TRAITEMENT OU LA PRÉVENTION D'UNE INFECTION À DIROFILARIA CHEZ UN MAMMIFÈRE
  申请人：[en]LIVERPOOL SCHOOL OF TROPICAL MEDICINE

  公开号：WO2022152918A1

  公开（公告）日：2022-07-21

  Provided is a compound of formula (I), or pharmaceutically acceptable salt or solvate thereof, as defined herein for use in the treatment or prevention of aDirofilariainfection in a mammal. The compounds are also for use in the treatment or prevention of diseases or conditions caused by aDirofilariainfection in a mammal. Also described are corresponding methods of treating or preventing aDirofilariainfection in a mammal.