4-Acetamino-1-(1-acetoxy-ethyl)-benzol | 68688-64-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Acetamino-1-(1-acetoxy-ethyl)-benzol
• 英文别名: 1-(1-acetoxy-ethyl)-4-acetylamino-benzene；1-(1-Acetoxy-aethyl)-4-acetylamino-benzol；4-Acetamino-1-(1-acetoxy-aethyl)-benzol；Methyl-(4-acetamino-phenyl)-carbinol-acetat；1-(4-Acetamidophenyl)ethyl acetate
• CAS: 68688-64-2
• 化学式: C₁₂H₁₅NO₃
• 分子量: 221.256
• InChiKey: XHNMUWHMTVPVQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-Acetamino-1-(1-acetoxy-ethyl)-benzol 、 烯丙基三甲基硅烷 在 碘 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以89%的产率得到N-(4-pent-4-en-2-ylphenyl)acetamide
  参考文献：
  名称：

  分子碘催化乙酸苄酯和肉桂醇的脱氧烯丙基化

  摘要：

  在温和条件下，在 10 mol% 分子碘的存在下，乙酸苄酯与烯丙基三甲基硅烷发生平稳的脱氧烯丙基化反应，以优异的产率和高选择性得到相应的烯丙基衍生物。肉桂醇在类似条件下也很容易与烯丙基硅烷反应。分子碘的使用使该方法变得非常简单、方便且经济有效。

  DOI：

  10.1246/cl.2007.1500
• 作为产物：
  描述：

  N-乙酰苯胺 在 二硫化碳 、 sodium tetrahydroborate 、 三氯化铝 作用下， 生成 4-Acetamino-1-(1-acetoxy-ethyl)-benzol
  参考文献：
  名称：

  Ferber; Brueckner, Chemische Berichte, 1939, vol. 72, p. 995,999, 1000

  摘要：

  DOI：

文献信息

• Synthesis of oxindole from acetanilide via Ir(<scp>iii</scp>)-catalyzed C–H carbenoid functionalization
  作者：Pitambar Patel、Gongutri Borah

  DOI：10.1039/c6cc08788d

  日期：——

  Herein we disclose the first report on synthesis of oxindole derivatives from acetanilide via Ir(III)-catalyzed intermolecular C-H functionalization with diazotized Meldrum's acid. A broad range of substituted anilides were found...

  在这里，我们公开了关于通过重氮化的Meldrum酸经Ir（III）催化的分子间CH官能化从乙酰苯胺合成羟吲哚衍生物的第一份报道。发现了范围广泛的取代的苯胺类化合物。
• The immobilized Cu nanoparticles on magnetic montmorillonite (MMT@Fe3O4@Cu): As an efficient and reusable nanocatalyst for reduction and reductive-acetylation of nitroarenes with NaBH4
  作者：Behzad Zeynizadeh、Soleiman Rahmani、Hengameh Tizhoush

  DOI：10.1016/j.poly.2019.114201

  日期：2020.1

  In this study, the immobilization of copper nanoparticles on superparamagnetic montmorillonite, MMT@Fe3O4@Cu, was studied. Magnetically nanoparticles (MNPs) of iron oxide (Fe3(O)4) were primarily prepared by a chemical co-precipitation method. Next, the prepared Fe3O4 MNPs were intercalated within the interlamellar spaces and external surface of sodium-exchanged montmorillonite. Finally, Cu NPs were immobilized on magnetic montmorillonite by a simply mixing of an aqueous solution of CuCl2.2H(2)O with MMT@Fe3O4 followed by the reduction with NaBH4. Characterization of MMT@Fe3O4 clay system represented that through the immobilization of Fe3O4 MNPs, disordered-layers structure of MMT was easily reorganized to an ordered-layers arrangement. The synthesized composite systems were characterized using FT-IR, SEM, EDX, XRD, VSM, BET and ICP-OES analyses. SEM analysis exhibited that dispersion of Cu NPs, with the size distribution of 15-25 nm, on the surface of magnetic clay was taken place perfectly. BET surface analysis indicated that after the immobilization of Fe3O4 and Cu species, the surface area and total pore volume of MMT@Fe3O4@Cu system was decreased. Next, the Cu-clay nanocomposite system showed a perfect catalytic activity towards reduction of nitroarenes to anilines as well as reductive-acetylation of nitroarenes to acetanilides using NaBH4 and Ac2O in water as a green and economic solvent. The copper magnetic clay catalyst can be easily separated from the reaction mixture by an external magnetic field and reused for six consecutive cycles without the significant loss of its catalytic activity. (C) 2019 Elsevier Ltd. All rights reserved.
• <b>Substituent Effects in Pyrolysis. V.^1,2 A <b><i>p</i></b>-σ⁺ Correlation in the Pyrolysis of 1-Arylethyl Acetates</b>
  作者：Roger. Taylor、Grant Gill. Smith、William H. Wetzel

  DOI：10.1021/ja00883a037

  日期：1962.12
• 1N-ALKYL-N-ARYLPYRIMIDINAMINES AND DERIVATIVES THEREOF
  申请人：THE DU PONT MERCK PHARMACEUTICAL COMPANY

  公开号：EP0723533A1

  公开（公告）日：1996-07-31
• US6107301A
  申请人：——

  公开号：US6107301A

  公开（公告）日：2000-08-22