(R)-3-(4'-(N-(3-(1-(2,3-dihydro-1H-inden-2-yl)-2-methylpropan-2-ylamino)-2-hydroxypropyl)-N-methylsulfamoyl)-2',5-difluorobiphenyl-2-yl)propionic acid | 1198610-91-1

• 分子结构分类: 有机化合物
• 英文名称: (R)-3-(4'-(N-(3-(1-(2,3-dihydro-1H-inden-2-yl)-2-methylpropan-2-ylamino)-2-hydroxypropyl)-N-methylsulfamoyl)-2',5-difluorobiphenyl-2-yl)propionic acid
• 英文别名: 3-[2-[4-[[(2R)-3-[[1-(2,3-dihydro-1H-inden-2-yl)-2-methylpropan-2-yl]amino]-2-hydroxypropyl]-methylsulfamoyl]-2-fluorophenyl]-4-fluorophenyl]propanoic acid
• CAS: 1198610-91-1
• 化学式: C₃₂H₃₈F₂N₂O₅S
• 分子量: 600.727
• InChiKey: PKXODHFMYMLPGL-AREMUKBSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  42
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  115
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• SULFONAMIDE COMPOUNDS AND THE USE
  申请人：OGAWA Masami

  公开号：US20100022601A1

  公开（公告）日：2010-01-28

  The sulfoneamide compounds having the following Formula (1), which can be used as an effective component of a CaSR antagonizing agent useful for prophylaxis and/or treatment of bone disorders including osteoporosis and etc., are provided. The compounds have an excellent activity of promoting PTH secretion. In addition, the compounds are useful as an effective component of a medicament for the prophylaxis and/or treatment of bone disorders such as osteoporosis, bone fracture, hypoparathyroidism and the like.

  提供以下式(1)的磺酰胺化合物，可用作预防或治疗包括骨质疏松症等骨疾病的CaSR拮抗剂的有效成分。这些化合物具有促进PTH分泌的卓越活性。此外，这些化合物还用作预防或治疗骨质疏松症、骨折、低甲状旁腺功能等骨疾病药物的有效成分。
• SULFONAMIDE COMPOUND AND APPLICATION THEREOF
  申请人：Asahi Kasei Pharma Corporation

  公开号：EP2292592A1

  公开（公告）日：2011-03-09

  The sulfoneamide compounds having the following Formula (1), which can be used as an effective component of a CaSR antagonizing agent useful for prophylaxis and/or treatment of bone disorders including osteoporosis and etc., are provided. The compounds have an excellent activity of promoting PTH secretion. In addition, the compounds are useful as an effective component of a medicament for the prophylaxis and/or treatment of bone disorders such as osteoporosis, bone fracture, hypoparathyroidism and the like.

  本发明提供了具有下式（1）的砜酰胺化合物，可用作预防和/或治疗骨质疏松症等骨病的 CaSR 拮抗剂的有效成分。这些化合物具有良好的促进 PTH 分泌的活性。此外，这些化合物还可作为预防和/或治疗骨质疏松症、骨折、甲状旁腺功能减退症等骨病的药物的有效成分。
• US8039514B2
  申请人：——

  公开号：US8039514B2

  公开（公告）日：2011-10-18