3-Hydroxy-2-hydroxymethyl-2-methyl-N-[3-(naphthalen-1-ylazo)-phenyl]-propionamide | 382617-08-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-Hydroxy-2-hydroxymethyl-2-methyl-N-[3-(naphthalen-1-ylazo)-phenyl]-propionamide
• CAS: 382617-08-5
• 化学式: C₂₁H₂₁N₃O₃
• 分子量: 363.416
• InChiKey: JPGUIRCXMYCQRR-WCWDXBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.18
• 重原子数：
  27.0
• 可旋转键数：
  6.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  94.28
• 氢给体数：
  3.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  3-Hydroxy-2-hydroxymethyl-2-methyl-N-[3-(naphthalen-1-ylazo)-phenyl]-propionamide 在 四氮唑 、 4-二甲氨基吡啶 作用下， 以 吡啶 、 二氯甲烷 、 乙腈 为溶剂， 生成 Diisopropyl-phosphoramidous acid 3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-methyl-2-[3-(naphthalen-1-ylazo)-phenylcarbamoyl]-propyl ester 2-cyano-ethyl ester
  参考文献：
  名称：

  Phenylazonaphthalene as a superb photo-regulator for DNA-triplex formation

  摘要：

  Phenylazonaphthalene was tethered to the 5'-end of oligo(T) as photo-responsive moiety for the photo-regulation of DNA-triplex formation. The melting temperature of DNA-triplex changed as greatly as 40.5 degreesC on trans <----> cis isomerization of phenylazonaphthalene. This change was much greater than that achieved by azobenzene. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01347-8
• 作为产物：
  描述：

  3-nitrophenyldiazonium chloride 在 盐酸 、 sodium hydrogensulfide 、 硫酸 、 亚膦酸 、 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 、 sodium nitrite 作用下， 以 乙醇 、 水 、 溶剂黄146 、 N,N-二甲基甲酰胺 为溶剂， 生成 3-Hydroxy-2-hydroxymethyl-2-methyl-N-[3-(naphthalen-1-ylazo)-phenyl]-propionamide
  参考文献：
  名称：

  Phenylazonaphthalene as a superb photo-regulator for DNA-triplex formation

  摘要：

  Phenylazonaphthalene was tethered to the 5'-end of oligo(T) as photo-responsive moiety for the photo-regulation of DNA-triplex formation. The melting temperature of DNA-triplex changed as greatly as 40.5 degreesC on trans <----> cis isomerization of phenylazonaphthalene. This change was much greater than that achieved by azobenzene. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01347-8