Aminopyrrolidine dihydrochloride | 1389313-46-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: Aminopyrrolidine dihydrochloride
• 英文别名: pyrrolidin-1-amine;dihydrochloride
• CAS: 1389313-46-5
• 化学式: C4H12Cl2N2
• mdl: MFCD19687039
• 分子量: 159.05
• InChiKey: MXAQYXXHPDEVDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.46
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.3
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2S)-8,9-difluoro-1,2-dihydro-2-methyl-6-oxo-6H-pyrrolo<3,2,1-ij>quinoline-5-carboxylic acid 、 Aminopyrrolidine dihydrochloride 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 在 盐酸 、 water ethanol 作用下， 以 六甲基磷酰三胺 为溶剂， 反应 2.0h， 以to obtain (+)-8-fluoro-2-methyl-9-(3-amino-1-pyrrolidyl)-6-oxo-1,2-dihydro-6H-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid hydrochloride的产率得到(+)-8-fluoro-2-(S)-methyl-9-(3-amino-1-pyrrolidinyl)-6-oxo-1,2-dihydro-6H-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid hydrochloride
  参考文献：
  名称：

  Pyrroloquinoline derivatives and pharmaceutical compositions for

  摘要：

  本文描述了一种一般式为：##STR1##的吡咯喹啉衍生物，其中R'是C.sub.1-C.sub.6烷基，R.sup.2是一种基团：##STR2##或一种基团：##STR3##其中R.sup.3，R.sup.4，R.sup.5和R.sup.6如定义，或其盐。这些化合物具有抗微生物活性。

  公开号：

  US05185337A1

文献信息

• Novel pyridobenzoxazine derivative
  申请人：WAKUNAGA SEIYAKU KABUSHIKI KAISHA

  公开号：EP0373531A1

  公开（公告）日：1990-06-20

  Pyridobenzoxazine derivatives having a [3,2,1-­ij][3,1]benzoxazine structure represented by the formula (I) and their salts are disclosed. There are many varieties for the compound depending on the types of residues R₁-R₄, X₁, and X₂. The compounds of formula (I) and their salts have excellent antimicrobial activities and wide antimicrobial spectra, and are effective against both gram positive and gram negative microorganisms. They can be used as a medicine, an agrichemical, and a food preservative.

  揭示了具有由公式(I)表示的[3,2,1-ij][3,1]苯并噁嗪结构的吡啶苯并噁嗪衍生物及其盐。根据残基R₁-R₄、X₁和X₂的类型，该化合物有许多不同的变体。公式(I)的化合物及其盐具有出色的抗微生物活性和广泛的抗微生物谱，对革兰氏阳性和革兰氏阴性微生物均有效。它们可用作药物、农药和食品防腐剂。
• Process for producing 1H-3-aminopyrrolidine and derivatives thereof
  申请人：Mitsubishi Chemical Corporation

  公开号：US20020042523A1

  公开（公告）日：2002-04-11

  A process for producing 1H-3-aminopyrrolidine and derivatives thereof is disclosed. The process is especially useful for producing optically active 1H-3-aminopyrrolidine and derivatives thereof and in this case comprises reacting an optically active amino-protected aspartic anhydride represented by the formula (1) with a primary amine represented by the formula R′NH 2 , subjecting the reaction product to cyclodehydration to obtain an optically active 1 -aralkyl-3-(protected amino)pyrrolidine-2,5-dione compound represented by the formula (2), subsequently eliminating the protective group from the 3-position amino group of the compound represented by the formula (2) to obtain an optically active 1-aralkyl-3-aminopyrrolidine-2,5-dione compound represented by the formula (3), reducing the carbonyl groups of the compound represented by the formula (3) to obtain either an optically active 1-aralkyl-3-aminopyrrolidine compound represented by the formula (4) or a salt thereof with a protonic acid, and then subjecting the compound represented by the formula (4) or the salt thereof to hydrogenolysis to obtain an optically active 1H-3-aminopyrrolidine or a protonic acid salt thereof.

  公开了一种生产1H-3-氨基吡咯烷及其衍生物的方法。该方法特别适用于生产光学活性的1H-3-氨基吡咯烷及其衍生物，其中包括将公式（1）表示的光学活性氨基保护的天冬氨酸酐与公式R'NH2表示的一级胺反应，将反应产物经过环化脱水作用得到公式（2）表示的光学活性1-芳基甲基-3-(保护氨基)吡咯烷-2,5-二酮化合物，随后消除公式（2）所表示的化合物中3位氨基基团的保护基，得到公式（3）表示的光学活性1-芳基甲基-3-氨基吡咯烷-2,5-二酮化合物，将公式（3）所表示的化合物的羰基基团还原，得到公式（4）表示的光学活性1-芳基甲基-3-氨基吡咯烷化合物或其与质子酸的盐，然后将公式（4）所表示的化合物或其盐进行氢解，得到光学活性的1H-3-氨基吡咯烷或其质子酸盐。
• 5-Substituted-1,4-dihydro-4-oxonaphthyridine-3-carboxylate antibacterial agents
  申请人：Bristol-Myers Squibb Company

  公开号：EP0387802A2

  公开（公告）日：1990-09-19

  The invention is concerned with naphthyridine compounds of formula (I) which are substituted in the 7-position with various nitrogen heterocyclo groups and at the 1,3,4,5 and 6-positions with certain other groups. These compounds are antibacterial agents and are suitable for the treatment of infections.

  本发明涉及式（I）的萘啶化合物，该化合物在 7 位被各种氮杂环基团取代，在 1、3、4、5 和 6 位被某些其他基团取代。这些化合物是抗菌剂，适用于治疗感染。
• Pyrroloquinoline derivatives, antimicrobial agents using the same and process for preparing the same
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP0390135A1

  公开（公告）日：1990-10-03

  There is described pyrroloquinoline derivatives of general formula: wherein R¹ is a C₁-C₆ alkyl group, R² is a group: or group: wherein R³, R⁴, R⁵ and R⁶ are as defined, or salt thereof. These compounds have an antimicrobial activity.

  所述吡咯喹啉衍生物通式如下 其中 R¹ 是 C₁-C₆ 烷基，R² 是一个基团： 或基团： 其中 R³、R⁴、R⁵ 和 R⁶ 如所定义，或其盐。这些化合物具有抗菌活性。
• Intermediates in the preparation of 4-oxoquinoline-3-carboxylic acid derivatives
  申请人：UBE INDUSTRIES, LTD.

  公开号：EP0610958A2

  公开（公告）日：1994-08-17

  Compounds of formula (XII), (XX), (XX'),(XXI) and in which R1 represents fluorinated methoxy, R3 represents hydrogen or amino, R3' represents hydrogen or nitro, R3" represents hydrogen, nitro or amino, X and X' represent halogen and R17 represents a carboxy protecting group, are useful in the preparation of 4-oxoquinoline-3-carboxylic acid derivatives.

  式(XII)、(XX)、(XX')、(XXI)和(XXI)化合物 其中 R1 代表氟化甲氧基，R3 代表氢或氨基，R3'代表氢或硝基，R3 "代表氢、硝基或氨基，X 和 X'代表卤素，R17 代表羧基保护基团，可用于制备 4-氧代喹啉-3-羧酸衍生物。