Amid der 3-(4-tert-Butyl-phenyl)-propionsaeure | 1208-62-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Amid der 3-(4-tert-Butyl-phenyl)-propionsaeure
• 英文别名: 3-(4-tert-Butyl-phenyl)-propionamid；3-(4-tert-butyl-phenyl)-propionic acid amide；3-(4-tert-Butyl-phenyl)-propionsaeure-amid；3-(4-Tert-butylphenyl)propanamide
• CAS: 1208-62-4
• 化学式: C₁₃H₁₉NO
• mdl: MFCD09188630
• 分子量: 205.3
• InChiKey: PMGXVJDKWIGUQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.461
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-(4-叔-丁基苯)丙酸,甲酯 生成 Amid der 3-(4-tert-Butyl-phenyl)-propionsaeure
  参考文献：
  名称：

  Tsatsas,G. et al., Bulletin de la Societe Chimique de France, 1964, p. 2615 - 2617

  摘要：

  DOI：

文献信息

• Palladium-catalyzed regiodivergent hydroaminocarbonylation of alkenes to primary amides with ammonium chloride
  作者：Bao Gao、Guoying Zhang、Xibing Zhou、Hanmin Huang

  DOI：10.1039/c7sc04054g

  日期：——

  the synthesis of primary amides has long been an elusive aim. Here, we report an efficient catalytic system which enables inexpensive NH4Cl to be utilized as a practical alternative to gaseous ammonia for the palladium-catalyzed alkene-hydroaminocarbonylation reaction. Through appropriate choice of the palladium precursors and ligands, either branched or linear primary amides can be obtained in good

  钯催化烯烃的氢氨基羰基化合成伯酰胺长期以来一直是一个难以实现的目标。在这里，我们报道了一种高效的催化系统，该系统能够利用廉价的 NH 4 Cl 作为气态氨的实际替代品，用于钯催化的烯烃-氢氨基羰基化反应。通过适当选择钯前体和配体，可以以良好的产率获得支链或直链伯酰胺，并具有良好至优异的区域选择性。进行了初步机理研究并揭示了亲电子酰基钯物质能够在 CO 存在下以 NMP 作为碱捕获铵盐中的 NH 2 -部分以形成酰胺。
• INDOLINE DERIVATIVES SUBSTITUTED IN THE 6 POSITION, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
  申请人：Roth Juergen Gerald

  公开号：US20070004757A1

  公开（公告）日：2007-01-04

  The present invention relates to indolinone derivatives, substituted in the 6-position, of the formula in which R 1 to R 6 and X are as defined in Claim 1 , to their tautomers, enantiomers, diastereomers, to their mixtures and to their salts, in particular their physiologically acceptable salts, which have useful pharmacological properties, in particular in inhibiting action on various receptor tyrosine kinases and on the proliferation of endothelial cells and various tumour cells, to medicaments comprising these compounds, to their use and to processes for their preparation.

  本发明涉及6-位取代的吲哚酮衍生物，其化学式为其中R1至R6和X如权利要求1所定义，以及它们的互变异构体、对映异构体、非对映异构体、混合物和盐，特别是其生理上可接受的盐，具有有用的药理学性质，特别是在抑制各种受体酪氨酸激酶和内皮细胞以及各种肿瘤细胞的增殖方面，以及包含这些化合物的药物、它们的用途和制备方法。
• INDOLINONE DERIVATIVES SUBSTITUTED IN THE 6 POSITION, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
  申请人：ROTH Gerald Juergen

  公开号：US20090197876A1

  公开（公告）日：2009-08-06

  The present invention relates to indolinone derivatives, substituted in the 6-position, of the formula in which R 1 to R 6 and X are as defined in Claim 1 , to their tautomers, enantiomers, diastereomers, to their mixtures and to their salts, in particular their physiologically acceptable salts, which have useful pharmacological properties, in particular in inhibiting action on various receptor tyrosine kinases and on the proliferation of endothelial cells and various tumour cells, to medicaments comprising these compounds, to their use and to processes for their preparation.

  本发明涉及6-位取代的吲哚酮衍生物，其化学式如下：其中R1至R6和X如权利要求1所定义，以及它们的互变异构体、对映异构体、非对映异构体、它们的混合物和它们的盐，特别是它们的生理上可接受的盐，具有有用的药理特性，特别是在抑制各种受体酪氨酸激酶和内皮细胞以及各种肿瘤细胞增殖方面，以及包含这些化合物的药物、它们的使用和它们的制备方法。
• Tsatsas et al., Bulletin de la Societe Chimique de France, 1964, p. 2615
  作者：Tsatsas et al.

  DOI：——

  日期：——
• US7169936B2
  申请人：——

  公开号：US7169936B2

  公开（公告）日：2007-01-30