(5-cyano-3-pyridyl)methylmethanesulfonate | 1268628-98-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (5-cyano-3-pyridyl)methylmethanesulfonate
• 英文别名: (5-cyanopyridin-3-yl)methyl methanesulfonate；(5-cyano-3-pyridinyl)methyl methanesulfonate
• CAS: 1268628-98-3
• 化学式: C₈H₈N₂O₃S
• 分子量: 212.229
• InChiKey: PWKKAWWRXCKISN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  88.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (5-cyano-3-pyridyl)methylmethanesulfonate 、 7-({4'-fluoro-2-methyl-[1,1'-biphenyl]-3-yl}methoxy)-5-hydroxy-2,3-dihydro-1H-indene-4-carbaldehyde 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以60.33 %的产率得到5-({[7-({4'-fluoro-2-methyl-[1,1'-biphenyl]-3-yl}methoxy)-4-formyl-2,3-dihydro-1H-inden-5-yl]oxy}methyl)pyridine-3-carbonitrile
  参考文献：
  名称：

  [EN] COMPOUNDS AS PD1/PD-L1 INHIBITORS AND METHODS THEREOF
  [FR] COMPOSÉS UTILISÉS EN TANT QU'INHIBITEURS DE PD1/PD-L1 ET PROCÉDÉS ASSOCIÉS

  摘要：

  The present invention relates in general, to the field of pharmaceutical compounds, more particularly to the compounds of Formula (I) which acts as inhibitors for PD1/PD-L1 interaction. The present invention further relates to a method of preparation of compounds of Formula (I). The present invention also relates to a composition of compounds of Formula (I).

  公开号：

  WO2022224278A1

文献信息

• IMMUNOMODULATOR COMPOUNDS
  申请人：CHEMOCENTRYX, INC.

  公开号：US20180008554A1

  公开（公告）日：2018-01-11

  Compounds are provided that are useful as immunomodulators. The compounds have the following Formula (II): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R 1 , R 2a , R 2b , R 2c , R 3 , R 4 , R 5 , R 6a , R 6b , m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

  提供了一些有用的免疫调节剂。这些化合物具有以下式（II）：包括其立体异构体和药用盐，其中R1、R2a、R2b、R2c、R3、R4、R5、R6a、R6b、m和n的定义如本文所述。还公开了与这些化合物的制备和使用相关的方法，以及包含这些化合物的药物组合物。
• Immunomodulator compounds
  申请人：CHEMOCENTRYX, INC.

  公开号：US10639284B2

  公开（公告）日：2020-05-05

  Compounds are provided that are useful as immunomodulators. The compounds have the following Formula (II): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2a, R2b, R2c, R3, R4, R5, R6a, R6b, m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

  本研究提供了可用作免疫调节剂的化合物。这些化合物具有下式（II）： 其中 R1、R2a、R2b、R2c、R3、R4、R5、R6a、R6b、m 和 n 如本文所定义。此外，还公开了与制备和使用此类化合物相关的方法，以及包含此类化合物的药物组合物。