5-(p-cyanobenzoyl)-2'-deoxyuridine | 213037-75-3

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 5-(p-cyanobenzoyl)-2'-deoxyuridine
• 英文别名: 4-[1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4-dioxopyrimidine-5-carbonyl]benzonitrile
• CAS: 213037-75-3
• 化学式: C₁₇H₁₅N₃O₆
• 分子量: 357.323
• InChiKey: BZTCSCHNKOQIGN-BFHYXJOUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  140
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  5-(p-cyanobenzoyl)-2'-deoxyuridine 在 四氮唑 、 4-二甲氨基吡啶 、 三乙胺 作用下， 以 吡啶 、 乙腈 为溶剂， 生成 4-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-2,4-dioxopyrimidine-5-carbonyl]benzonitrile
  参考文献：
  名称：

  p-Cyano substituted 5-benzoyldeoxyuridine as a novel electron-accepting nucleobase for one-electron oxidation of DNA

  摘要：

  p-Cyano substituted 5-benzoyl-2'-deoxyuridine 1 was synthesized as a novel electron-accepting nucleobase. DNA cleavage by 1 under photoirradiation conditions occurred selectively at the 5'-G of 5'GG3' sequences after hot piperidine treatment. Photoirradiation of 1 in the presence of dG produced imidazolone as a major product. The electron-accepting nucleobase 1 was successfully incorporated into DNA oligomer by automated DNA synthesis using phosporamidite 2. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)01231-3
• 作为产物：
  描述：

  4-[1-[(2R,4S,5R)-4-[tert-butyl(dimethyl)silyl]oxy-5-[[tert-butyl(dimethyl)silyl]oxymethyl]oxolan-2-yl]-2,4-dioxopyrimidine-5-carbonyl]benzonitrile 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 以94%的产率得到5-(p-cyanobenzoyl)-2'-deoxyuridine
  参考文献：
  名称：

  p-Cyano substituted 5-benzoyldeoxyuridine as a novel electron-accepting nucleobase for one-electron oxidation of DNA

  摘要：

  p-Cyano substituted 5-benzoyl-2'-deoxyuridine 1 was synthesized as a novel electron-accepting nucleobase. DNA cleavage by 1 under photoirradiation conditions occurred selectively at the 5'-G of 5'GG3' sequences after hot piperidine treatment. Photoirradiation of 1 in the presence of dG produced imidazolone as a major product. The electron-accepting nucleobase 1 was successfully incorporated into DNA oligomer by automated DNA synthesis using phosporamidite 2. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)01231-3
• 作为试剂：
  描述：

  2'-脱氧鸟苷 在 5-(p-cyanobenzoyl)-2'-deoxyuridine 作用下， 以 various solvent(s) 为溶剂， 反应 3.0h， 生成 2-amino-5-[(2'-deoxy-β-D-erythro-pentofuranosyl)amino]-4H-imidazol-4-one
  参考文献：
  名称：

  p-Cyano substituted 5-benzoyldeoxyuridine as a novel electron-accepting nucleobase for one-electron oxidation of DNA

  摘要：

  p-Cyano substituted 5-benzoyl-2'-deoxyuridine 1 was synthesized as a novel electron-accepting nucleobase. DNA cleavage by 1 under photoirradiation conditions occurred selectively at the 5'-G of 5'GG3' sequences after hot piperidine treatment. Photoirradiation of 1 in the presence of dG produced imidazolone as a major product. The electron-accepting nucleobase 1 was successfully incorporated into DNA oligomer by automated DNA synthesis using phosporamidite 2. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)01231-3